Results 101 to 110 of about 83,753 (298)

Adaptive radiation strategy with V20 limitation associates with survival benefit and lower incidence of symptomatic radiation pneumonitis in stage III NSCLC patients receiving concurrent immunotherapy and thoracic radiation

Translational Oncology
Objectives: To evaluate the efficacy and the incidence of symptomatic radiation pneumonitis (RP) of the adaptive radiation strategy with V20 limitation in stage III non-small cell lung cancer (NSCLC) patients receiving concurrent immunotherapy and ...
Zewen Song, Xi Zhang, Yechen Ma, Shuyun Ma, Ziyang Feng, Xuewen Liu   +5 more
doaj   +1 more source

Optimization of spatiotemporally fractionated radiotherapy treatments with bounds on the achievable benefit

, 2017
Spatiotemporal fractionation schemes, that is, treatments delivering different dose distributions in different fractions, may lower treatment side effects without compromising tumor control.
Gaddy, Melissa R., Papp, Dávid, Unkelbach, Jan, Yıldız, Sercan   +3 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Online radiotherapy—the paradigm shift to real-time adaptive radiotherapy

Deutsches Ärzteblatt international
Adaptive radiotherapy (ART) involves the continuous adaptation of the radiation plan according to patient- and tumor-specific feedback. In online ART, the plan is optimized in real time during the treatment; in offline ART, the plan is recalculated between treatment sessions.
Kalinauskaite, Goda, Nikolaou, Konstantin, Wittig, Andrea, Zips, Daniel, Zöphel, Klaus, Senger, Carolin   +5 more
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Direct inverse deformation field approach to pelvic-area symmetric image registration [PDF]

, 2011
This paper presents a novel technique for a consistent symmetric deformable image registration based on an accurate method for a direct inversion of a large motion model deformation field.
Matuszewski, Bogdan J, Papiez, Bartek
core  

Four-dimensional Cone Beam CT Reconstruction and Enhancement using a Temporal Non-Local Means Method

, 2012
Four-dimensional Cone Beam Computed Tomography (4D-CBCT) has been developed to provide respiratory phase resolved volumetric imaging in image guided radiation therapy (IGRT).
Ahmad, Bergner, Buades, Combettes, Coupe, Dietrich, Feldkamp, Gilboa, Golub, Gu, Gu, Gu, Gu, Hale, Herk, Hestenes, Hissoiny, Jan-Jakob Sonke, Jia, Jia, Jia, Jia, Jia, Kriminski, Leng, Leng, Li, Li, Li, Lou, Lu, Lu, Men, Men, Samant, Segars, Sharp, Siddon, Sonke, Steve B. Jiang, Tian, Xu, Xun Jia, Yifei Lou, Zhang, Zhen Tian, Zijp   +46 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Robust Real-Time Cancer Tracking via Dual-Panel X-Ray Images for Precision Radiotherapy

Bioengineering
Respiratory-induced tumor motion presents a critical challenge in lung cancer radiotherapy, potentially impacting treatment precision and efficacy. This study introduces an innovative, deep learning-based approach for real-time, markerless lung tumor ...
Jing Wang, Jingjing Dai, Na Li, Chulong Zhang, Jiankai Zhang, Zuledesi Silayi, Haodi Wu, Yaoqing Xie, Xiaokun Liang, Huailing Zhang   +9 more
doaj   +1 more source