Results 71 to 80 of about 56,790 (264)

Adaptive finite element analysis of thermal and elasticity problems using Zienkiewicz–Zhu recovery-based error estimation

open access: yesJournal of Nigerian Society of Physical Sciences
This paper presents a verification-to-adaptivity analysis of a finite element framework for scalar and vector-valued elliptic problems that employs recovery-based a posteriori error estimation. Conforming bilinear quadrilateral (Q4) and linear triangular
J. K. Odeyemi, S. A. Odunlami
doaj   +1 more source

Adaptive Grid Use in Air Quality Modeling

open access: yesAtmosphere, 2011
The predictions from air quality models are subject to many sources of uncertainty; among them, grid resolution has been viewed as one that is limited by the availability of computational resources.
Mehmet Talat Odman   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Sledgehamr: Simulating Scalar Fields with Adaptive Mesh Refinement

open access: yesThe Astrophysical Journal
Understanding the nonlinear dynamics of coupled scalar fields often necessitates simulations on a 3D mesh. These simulations can be computationally expensive if a large scale separation is involved.
Malte Buschmann
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Error Estimation for Adaptive Mesh Refinement in Droplet Simulations

open access: yesFluids
We present a one-dimensional shear-force-driven droplet formation model with a flux-based error estimator. The model is derived using asymptotic expansion and a front-tracking method to simulate the droplet interface.
Darsh Nathawani, Matthew Knepley
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The Stratified Ocean Model With Adaptive Refinement (SOMARv2)

open access: yesJournal of Advances in Modeling Earth Systems
Numerical studies of submesoscale ocean dynamics are restricted by several challenges, including its vast range of scales, nonhydrostatic features, and strong anisotropy.
Edward Santilli   +2 more
doaj   +1 more source

Improvement in the Accuracy and Efficiency of Smoothed Particle Hydrodynamics: Point Generation and Adaptive Particle Refinement/Coarsening Algorithms

open access: yesActuators
An adaptive particle refinement (APR) algorithm has been developed for the smoothed particle hydrodynamics (SPH) method to augment the resolution of the region of interest to achieve high accuracy and simultaneously reduce the cost of computational ...
Jun Zhang   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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