Results 101 to 110 of about 5,787,644 (326)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Adaptive Incremental Mixture Markov chain Monte Carlo
, 2018 We propose Adaptive Incremental Mixture Markov chain Monte Carlo (AIMM), a novel approach to sample from challenging probability distributions defined on a general state-space.
Friel, Nial +3 more
core +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
IEEE AccessThis study investigates whether interpretable adaptive difficulty regulation in game-based learning enhances learning achievement and creative self-efficacy in artistic anatomy education.
Guo Xinming +2 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Research and Application of an Improved Sparrow Search Algorithm
Applied SciencesAssociation rule mining utilizing metaheuristic algorithms is a prominent area of study in the field of data mining. However, when working with extensive data, conventional metaheuristic algorithms exhibit limited search efficiency and face challenges in
Liwei Hu, Denghui Wang
doaj +1 more source
Risk-Adaptive Local Decision Rules
Operations ResearchThe decision rules developed in this paper help managers recognize relationships between data and decisions and prescribe courses of actions that are guaranteed near-optimal as well as transparent and interpretable. Transparency and interpretability are prerequisites for any decision support tool that needs to be conveyed, understood, and justified ...
Johannes O. Royset, Miguel A. Lejeune
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Enhanced Numerical Techniques for Selective Integration Using Error Correction Methods
Ibn Al-Haitham Journal for Pure and Applied SciencesClassical numerical integration methods, such as Simpson’s rule and Gaussian quadrature, perform well for smooth functions but lose accuracy near discontinuities.
Israa Essa Abed, Wafaa M. R. Shakir
doaj +1 more source
International Journal of Antennas and Propagation, 2018 Degree of freedom (DOF) of clutter in the reduced-dimension (RD) domain, which is called local DOF (LDOF), is of great importance for RD MIMO-STAP (space-time adaptive processing for multiple-input multiple-output radar) algorithms.
Yiduo Guo, Jian Gong, Yu Xiao
doaj +1 more source