Results 111 to 120 of about 126,229 (309)
On Deriving Adaptation Rule Confidence from the Rule Generation Process [PDF]
, 2013 Previous case-based reasoning research makes a compelling case for the importance of CBR systems determining the system’s confidence in its conclusions, and has developed useful analyses of how characteristics of individual cases and the case base as a whole influence confidence.
Vahid Jalali, David Leake
openaire +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Enhanced Numerical Techniques for Selective Integration Using Error Correction Methods
Ibn Al-Haitham Journal for Pure and Applied SciencesClassical numerical integration methods, such as Simpson’s rule and Gaussian quadrature, perform well for smooth functions but lose accuracy near discontinuities.
Israa Essa Abed, Wafaa M. R. Shakir
doaj +1 more source
International Journal of Antennas and Propagation, 2018 Degree of freedom (DOF) of clutter in the reduced-dimension (RD) domain, which is called local DOF (LDOF), is of great importance for RD MIMO-STAP (space-time adaptive processing for multiple-input multiple-output radar) algorithms.
Yiduo Guo, Jian Gong, Yu Xiao
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Supporting authoring of adaptive hypermedia [PDF]
It is well-known that students benefit from personalised attention. However, frequently teachers are unable to provide this, most often due to time constraints.
Hendrix, Maurice
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Adaptive cluster sampling with a data driven stopping rule
, 2010 Adaptive cluster sampling, Monte carlo simulation, Stopping rule, Efficiency,
Stefano Gattone +6 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source