Results 91 to 100 of about 4,949,103 (256)

MODELS FOR INTRALAMINAR DAMAGE AND FAILURE OF FIBER COMPOSITES - A REVIEW

open access: yesFacta Universitatis. Series: Mechanical Engineering, 2016
In order to fully exploit the potential of structures made from fiber composites, designers need to know how damage occurs and develops and under what conditions the structure finally fails.
Klaus Rohwer
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

The Use of Variable Stiffness Joints in Adaptive Structures [PDF]

open access: yes, 2017
Adaptive structures are defined here as structures capable of counteracting actively the effect of external loads via controlled shape changes and redirection of the internal load path. These structures are integrated with sensors (e.g.
Wang, Q.   +9 more
core   +3 more sources

An analytical nonlinear morphing model for corrugated laminates

open access: yesCurved and Layered Structures, 2019
This paper contributes an analytical nonlinear morphing model for high-amplitude corrugated thinwalled laminates of arbitrary stack-up with a corrugation shape composed of circular sections.
Kress G.R., Filipovic D.T.
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Performance Evaluation of Structural Health Monitoring System Applied to Full-Size Composite Wing Spar via Probability of Detection Techniques

open access: yesSensors
Probability of detection (POD) is an acknowledged mean of evaluation for many investigations aiming at detecting some specific property of a subject of interest.
Bernardino Galasso   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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