Results 101 to 110 of about 7,727,216 (292)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2003 This paper provides a broad overview of the multiuser detection literature of the past few years in a nonmathematical, easily accessible approach. The treatment is then extended to the comparative study of channel-quality controlled burst-by-burst (BbB ...
Kuan, E.L., Hanzo, L.
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Two spatiotemporally distinct value systems shape reward-based learning in the human brain [PDF]
, 2015 Avoiding repeated mistakes and learning to reinforce rewarding decisions is critical for human survival and adaptive actions. Yet, the neural underpinnings of the value systems that encode different decision-outcomes remain elusive.
Mullinger, Karen J. +7 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Dynamic Channel Allocation Techniques Using Adaptive Modulation and Adaptive Antennas
, 2001 This contribution studies the impact of adaptive quadrature amplitude modulation (AQAM) on network performance when applied to a cellular network, using adaptive antennas in conjunction with both fixed channel allocation (FCA) and locally distributed ...
Blogh, J.S., Cherriman, P.J., Hanzo, L.
core +1 more source
Dianxin kexue, 2023 In the control of network terminal power, due to the overall low analysis of network state, the adaptive regulation ability of communication network terminal power is poor.Therefore, the power line carrier communication network terminal power control ...
Hong XUE +4 more
doaj +2 more sources
On the Adaptive Value of Mood and Mood Contagion
, 2022 We are presenting a study on mood that purports to contribute to an understanding of its evolution as a personal strategy and as a prosocial automatic contagion-based mechanism that both improve decision making. We present an environment where an agent interacts with objects of varying difficulty and where its mood is both a dispositional factor that ...
openaire +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source