FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
The adaptive value of probability distortion and risk-seeking in macaques' decision-making. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2021 Nioche A +5 more
europepmc +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Adaptive value of foot-and-mouth disease virus capsid substitutions with opposite effects on particle acid stability. [PDF]
Sci Rep, 2021 Caridi F +7 more
europepmc +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Linking ecological niche models and common garden experiments to predict phenotypic differentiation in stressful environments: Assessing the adaptive value of marginal populations in an alpine plant. [PDF]
Glob Chang Biol, 2022 Morente-López J +6 more
europepmc +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Adaptive Novelty Detection with Generalized Extreme Value Distribution
, 2018 This paper introduces the new adaptive novelty detection method. The proposed method is using generalized extreme value distribution to evaluate the absolute value of adaptive system weight increments in time.
Jan Vrba, Vrba, Jan
core +1 more source
Assessment of the Performance of the Adaptive Thresholding Algorithm for QRS Detection with the Use of AHA Database [PDF]
Bioautomation, 2007 Two modifications of an adaptive thresholding algorithm for heart beat detection have already been developed. The threshold combines three parameters: an adaptive slewrate value, a second value which rises when high-frequency noise occurs, and a third ...
Ivaylo Christov
doaj
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source