Results 121 to 130 of about 2,045,959 (299)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The Adaptive Value of Chromosomal Inversions and Climatic Change-Studies on the Natural Populations of Drosophila subobscura from the Balkans. [PDF]
Insects, 2023 Zivanovic G, Arenas C, Mestres F.
europepmc +1 more source
SARA: Singular-Value Based Adaptive Low-Rank Adaption
With the increasing number of parameters in large pre-trained models, LoRA as a parameter-efficient fine-tuning(PEFT) method is widely used for not adding inference overhead. The LoRA method assumes that weight changes during fine-tuning can be approximated by low-rank matrices.
Gu, Jihao +4 more
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On the Adaptive Value of Paranormal Beliefs - a Qualitative Study. [PDF]
Integr Psychol Behav Sci, 2021 Betsch T +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Range-Adaptive Value Representation in Different Stages of Schizophrenia: A Proof of Concept Study. [PDF]
Schizophr Bull, 2021 Wang LL +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The adaptive value of probability distortion and risk-seeking in macaques' decision-making. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2021 Nioche A +5 more
europepmc +1 more source
On the ergodicity properties of some adaptive MCMC algorithms
, 2005 In this paper we study the ergodicity properties of some adaptive Markov chain Monte Carlo algorithms (MCMC) that have been recently proposed in the literature.
Andrieu, Christophe, Moulines, Éric
core +3 more sources