Results 211 to 220 of about 40,794 (233)

Aicardi-Goutieres Syndrome Associated ADAR G1007R mutation dominantly induces neuroinflammation in mouse brain

Xinfeng Guo, Jiajun Liu, Chaowei Shang, Christopher J. Guerriero, Clayton A. Wiley, Richard A. Steinman, Yi Sheng, Jeffrey L. Brodsky, Timothy R. Billiar, Silvia Liu, Qingde Wang   +10 more
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A molecular proximity sensor based on an engineered, dual-component guide RNA. [PDF]

Elife
Choi J, Chen W, Liao H, Li X, Shendure J.   +4 more
europepmc   +1 more source

Metagenomics identification of genetically distinct tick virome in India unveils signs of purifying selection, and APOBEC and ADAR editing

Perumal Arumugam Desingu, ARUNKUMAR SELVARAYAR, K. Nagarajan, G. Saikumar   +3 more
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Conformational reorganization and phase separation drive hyper-editing of ADR-2-ADBP-1 complex. [PDF]

Nucleic Acids Res
Mu J, Wu C, Xu K, Liu X, Fu Y, Zhang Z, Yu J, Xue C, Wang Z, Chen X, Chen Y, Ou G, Liu Z.   +12 more
europepmc   +1 more source

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RNA Editing by Mammalian ADARs

2011
The main type of RNA editing in mammals is the conversion of adenosine to inosine which is translated as if it were guanosine. The enzymes that catalyze this reaction are ADARs (adenosine deaminases that act on RNA), of which there are four in mammals, two of which are catalytically inactive. ADARs edit transcripts that encode proteins expressed mainly
Simona Paro, Marion C. Hogg, Liam Keegan, Mary A O'Connell   +3 more
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Regulation and Functions of ADAR in Drosophila

2011
Drosophila melanogaster has a single Adar gene encoding a protein related to mammalian ADAR2 that edits transcripts encoding glutamate receptor subunits. We describe the structure of the Drosophila Adar locus and use ModENCODE information to supplement published data on Adar gene transcription, and splicing.
Simona Paro, Xianghua Li, Liam Keegan, Mary A O'Connell   +3 more
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Purification and Assay of ADAR Activity

2007
ADAR editing enzymes are found in all multicellular animals and are conserved in sequence and protein organization. The number of ADAR genes differs between animals, ranging from three in mammals to one in Drosophila. ADAR is also alternatively spliced to generate isoforms that can differ significantly in enzymatic activity.
Joshua J. C. Rosenthal, Liam Keegan, Loretta M. Roberson, Mary A O'Connell   +3 more
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ADAR and Immune Silencing in Cancer

Trends in Cancer, 2019
The regulation of immune responses by tumors is central to their survival. By diminishing the production of interferon (IFN) and other inflammatory mediators, tumors enhance immune evasion. Responses initiated by nucleic acid sensors and triggered by dysregulated RNA transcription and cytoplasmic DNA undergo down-modulation in tumors.
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Role of ADARs in Mouse Development

2011
RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency ...
Jochen C. Hartner, Carl R. Walkley, Brian J. Liddicoat   +2 more
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ADAR Proteins: Structure and Catalytic Mechanism

2011
Since the discovery of the adenosine deaminase (ADA) acting on RNA (ADAR) family of proteins in 1988 (Bass and Weintraub, Cell 55:1089-1098, 1988) (Wagner et al. Proc Natl Acad Sci U S A 86:2647-2651, 1989), we have learned much about their structure and catalytic mechanism.
Peter A. Beal, Mark R. Macbeth, Rena A. Goodman   +2 more
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