Results 211 to 220 of about 42,601 (251)

ADAR and Immune Silencing in Cancer

Trends in Cancer, 2019
The regulation of immune responses by tumors is central to their survival. By diminishing the production of interferon (IFN) and other inflammatory mediators, tumors enhance immune evasion. Responses initiated by nucleic acid sensors and triggered by dysregulated RNA transcription and cytoplasmic DNA undergo down-modulation in tumors.
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Editing specificity of ADAR isoforms

Adenosine to inosine deaminases acting on RNA (ADARs) enzymes are found in all metazoa. Their sequence and protein organization is conserved but also shows distinct differences. Moreover, the number of ADAR genes differs between organisms, ranging from one in flies to three in mammals.
Cornelia, Vesely, Michael F, Jantsch
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Purification and Assay of ADAR Activity

2007
ADAR editing enzymes are found in all multicellular animals and are conserved in sequence and protein organization. The number of ADAR genes differs between animals, ranging from three in mammals to one in Drosophila. ADAR is also alternatively spliced to generate isoforms that can differ significantly in enzymatic activity.
Liam P, Keegan, Joshua J, Rosenthal, Loretta M, Roberson, Mary A, O'Connell   +3 more
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Role of ADARs in Mouse Development

2011
RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency ...
Carl R, Walkley, Brian, Liddicoat, Jochen C, Hartner   +2 more
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Downslope flow observations near Cape Adare shelf-break

Antarctic Science, 2004
The analysis of two high resolution hydrological datasets acquired during the 1997 and 2001 summers across the Antarctic continental shelf-break near Cape Adare (Ross Sea) is presented. The main focus of these cruises was the investigation of the overflow of the High Salinity Shelf Water (HSSW). This dense and salty water mass forms along Victoria Land
BERGAMASCO A, DEFENDI V, BUDILLON, Giorgio, SPEZIE G.   +3 more
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irCLASH reveals RNA substrates recognized by human ADARs

Nature Structural & Molecular Biology, 2020
Adenosine deaminases acting on RNA (ADARs) convert adenosines to inosines in double-stranded RNA (dsRNA) in animals. Despite their importance, ADAR RNA substrates have not been mapped extensively in vivo. Here we develop irCLASH to map RNA substrates recognized by human ADARs and uncover features that determine their binding affinity and editing ...
Yulong Song, Wenbing Yang, Qiang Fu, Liang Wu, Xueni Zhao, Yusen Zhang, Rui Zhang   +6 more
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Adenosine Deaminases That Act on RNA (ADARs)

2017
Inosine is one of the most common modifications found in human RNAs and the Adenosine Deaminases that act on RNA (ADARs) are the main enzymes responsible for its production. ADARs were first discovered in the 1980s and since then our understanding of ADARs has advanced tremendously.
Yuru, Wang, Yuxuan, Zheng, Peter A, Beal
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Regulation and Functions of ADAR in Drosophila

2011
Drosophila melanogaster has a single Adar gene encoding a protein related to mammalian ADAR2 that edits transcripts encoding glutamate receptor subunits. We describe the structure of the Drosophila Adar locus and use ModENCODE information to supplement published data on Adar gene transcription, and splicing.
Simona, Paro, Xianghua, Li, Mary A, O'Connell, Liam P, Keegan   +3 more
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Adar: Adversarial Activity Recognition in Wearables

2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD), 2019
Recent advances in machine learning and deep neural networks have led to the realization of many important applications in the area of personalized medicine. Whether it is detecting activities of daily living or analyzing images for cancerous cells, machine learning algorithms have become the dominant choice for such emerging applications.
Ramesh Kumar Sah, Hassan Ghasemzadeh
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Ein Winter am Kap Adare

1910
Der Winter stand jetzt vor uns, die Temperatur sank schnell, als die Sonne uns verlies und die Kalte wurde empfindlich.
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