Results 221 to 230 of about 40,794 (233)

Adenosine Deaminases That Act on RNA (ADARs)

2017
Inosine is one of the most common modifications found in human RNAs and the Adenosine Deaminases that act on RNA (ADARs) are the main enzymes responsible for its production. ADARs were first discovered in the 1980s and since then our understanding of ADARs has advanced tremendously.
Yuxuan Zheng, Peter A. Beal, Yuru Wang
openaire   +3 more sources

Adar: Adversarial Activity Recognition in Wearables

2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD), 2019
Recent advances in machine learning and deep neural networks have led to the realization of many important applications in the area of personalized medicine. Whether it is detecting activities of daily living or analyzing images for cancerous cells, machine learning algorithms have become the dominant choice for such emerging applications.
Hassan Ghasemzadeh, Ramesh Kumar Sah
openaire   +2 more sources

Editing specificity of ADAR isoforms

Adenosine to inosine deaminases acting on RNA (ADARs) enzymes are found in all metazoa. Their sequence and protein organization is conserved but also shows distinct differences. Moreover, the number of ADAR genes differs between organisms, ranging from one in flies to three in mammals.
Cornelia, Vesely, Michael F, Jantsch
openaire   +2 more sources

ADARs, RNA editing and more in hematological malignancies

Leukemia, 2020
Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in humans, mediated by the adenosine deaminases acting on RNA (ADARs). Physiologically, these enzymes are present in the nucleus and/or the cytoplasm, where they catalyze the conversion of adenosines (A) to inosines (I) on double-stranded mRNA molecules.
Phaik Ju Teoh, Mun Yee Koh, Wee Joo Chng
openaire   +3 more sources

Modulation of MicroRNA Expression and Function by ADARs

2011
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by preventing the translation of specific messenger RNAs. Adenosine deaminases acting on RNAs (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing, the conversion of adenosines into inosines, in double-stranded RNAs. Because inosine preferentially base pairs with cytidine,
Kazuko Nishikura, Bjorn-Erik Wulff
openaire   +3 more sources

The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function

2010
From analysis of deep-sequencing data it is apparent that sequence differences occur between the genome and miRNAs. Changes from genomic A to an apparent G in miRNA can be accounted for by the editing activity of ADARs. Questions that arise from this observation are: How many miRNAs are edited and to what frequency?
Liam Keegan, Bret S E Heale, Mary A O'Connell   +2 more
openaire   +4 more sources

A-to-I RNA editing: The “ADAR” side of human cancer

Seminars in Cell & Developmental Biology, 2012
Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human ...
Galeano, Federica, Tomaselli, Sara, Locatelli, Franco, Gallo, Angela   +3 more
openaire   +3 more sources

Ein Winter am Kap Adare

1910
Der Winter stand jetzt vor uns, die Temperatur sank schnell, als die Sonne uns verlies und die Kalte wurde empfindlich.
openaire   +2 more sources

Following ADAR

Nature Chemical Biology, 2012
openaire   +2 more sources

RNA editing with endogenous ADARs

Nature Methods, 2019
openaire   +3 more sources