Results 231 to 240 of about 43,703 (264)

Adar-associated Aicardi Goutières syndrome in a child with bilateral striatal necrosis and recurrent episodes of transaminitis

BMJ Case Reports, 2023
Aicardi-Goutières syndrome (AGS) refers to a group of genetic diseases characterised by severe inflammatory encephalopathy that usually present within the first year of life, resulting in progressive loss of cognition, spasticity, dystonia and motor ...
R. van Toorn, Magriet van Niekerk, Shahida Moosa, P. Goussard, R. Solomons   +4 more
semanticscholar   +1 more source

An RNA G-Quadruplex Structure within the ADAR 5'UTR Interacts with DHX36 Helicase to Regulate Translation.

Angewandte Chemie, 2022
RNA G-quadruplex (rG4) structures in the 5' untranslated region (5'UTR) play crucial roles in fundamental cellular processes. ADAR is an important enzyme that binds to double-strand RNA and accounts for the conversion of Adenosine to Inosine in RNA ...
Kaixin Lyu, Shuo-Bin Chen, E. Y. Chow, Haizhou Zhao, Jia-Hao Yuan, Meng Cai, Jiahai Shi, T. Chan, Jia-Heng Tan, C. Kwok   +9 more
semanticscholar   +1 more source

Building a content-based recommendation engine model using Adamic Adar Measure; A Netflix case study

Mediterranean Conference on Embedded Computing, 2022
The volume of multimedia data on the Internet is constantly increasing. Nowadays, the most challenging task for Internet users is to extract and use these data smoothly and efficiently.
Abdullah Havolli, Arianit Maraj, Lorik Fetahu   +2 more
semanticscholar   +1 more source

Design of nonlinear controller based on ADAR method for wedge balancing

International Conference on Control, Automation and Systems, 2022
In this article, the author presented the application of principles and ADAR methods in synergetic control theory to synthesize an inverted wedge-balanced stable controller. Synergetic control theory is based on the principle of self-organization through
Chiem Nguyen Xuan, Le Tran Thang
semanticscholar   +1 more source

RNA Editing by Mammalian ADARs

2011
The main type of RNA editing in mammals is the conversion of adenosine to inosine which is translated as if it were guanosine. The enzymes that catalyze this reaction are ADARs (adenosine deaminases that act on RNA), of which there are four in mammals, two of which are catalytically inactive. ADARs edit transcripts that encode proteins expressed mainly
Simona Paro, Marion C. Hogg, Liam Keegan, Mary A O'Connell   +3 more
openaire   +3 more sources

ADAR Dysfunction in Brain Aging and Alzheimer's Disease

The FASEB Journal, 2022
Neuroinflammation is a central mechanism of brain aging and neurodegenerative disease, but why neuroinflammation develops with aging is incompletely understood.
Cali M. McEntee, Alyssa N. Cavalier, T. LaRocca   +2 more
semanticscholar   +1 more source

Purification and Assay of ADAR Activity

2007
ADAR editing enzymes are found in all multicellular animals and are conserved in sequence and protein organization. The number of ADAR genes differs between animals, ranging from three in mammals to one in Drosophila. ADAR is also alternatively spliced to generate isoforms that can differ significantly in enzymatic activity.
Joshua J. C. Rosenthal, Liam Keegan, Loretta M. Roberson, Mary A O'Connell   +3 more
openaire   +3 more sources

ADAR and Immune Silencing in Cancer

Trends in Cancer, 2019
The regulation of immune responses by tumors is central to their survival. By diminishing the production of interferon (IFN) and other inflammatory mediators, tumors enhance immune evasion. Responses initiated by nucleic acid sensors and triggered by dysregulated RNA transcription and cytoplasmic DNA undergo down-modulation in tumors.
openaire   +3 more sources

Regulation and Functions of ADAR in Drosophila

2011
Drosophila melanogaster has a single Adar gene encoding a protein related to mammalian ADAR2 that edits transcripts encoding glutamate receptor subunits. We describe the structure of the Drosophila Adar locus and use ModENCODE information to supplement published data on Adar gene transcription, and splicing.
Simona Paro, Xianghua Li, Liam Keegan, Mary A O'Connell   +3 more
openaire   +3 more sources

Role of ADARs in Mouse Development

2011
RNA editing by deamination of adenosine to inosine (A-to-I editing) is a physiologically important posttranscriptional mechanism that can regulate expression of genes by modifying their transcripts. A-to-I editing is mediated by adenosine deaminases acting on RNA (ADAR) that can catalytically exchange adenosines to inosines, with varying efficiency ...
Jochen C. Hartner, Carl R. Walkley, Brian J. Liddicoat   +2 more
openaire   +3 more sources