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ADAR Proteins: Structure and Catalytic Mechanism
2011Since the discovery of the adenosine deaminase (ADA) acting on RNA (ADAR) family of proteins in 1988 (Bass and Weintraub, Cell 55:1089-1098, 1988) (Wagner et al. Proc Natl Acad Sci U S A 86:2647-2651, 1989), we have learned much about their structure and catalytic mechanism.
Peter A. Beal +2 more
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Adenosine Deaminases That Act on RNA (ADARs)
2017Inosine is one of the most common modifications found in human RNAs and the Adenosine Deaminases that act on RNA (ADARs) are the main enzymes responsible for its production. ADARs were first discovered in the 1980s and since then our understanding of ADARs has advanced tremendously.
Yuxuan Zheng, Peter A. Beal, Yuru Wang
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Adar: Adversarial Activity Recognition in Wearables
2019 IEEE/ACM International Conference on Computer-Aided Design (ICCAD), 2019Recent advances in machine learning and deep neural networks have led to the realization of many important applications in the area of personalized medicine. Whether it is detecting activities of daily living or analyzing images for cancerous cells, machine learning algorithms have become the dominant choice for such emerging applications.
Hassan Ghasemzadeh, Ramesh Kumar Sah
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ADARs, RNA editing and more in hematological malignancies
Leukemia, 2020Adenosine-to-inosine (A-to-I) editing is the most prevalent type of RNA editing in humans, mediated by the adenosine deaminases acting on RNA (ADARs). Physiologically, these enzymes are present in the nucleus and/or the cytoplasm, where they catalyze the conversion of adenosines (A) to inosines (I) on double-stranded mRNA molecules.
Phaik Ju Teoh, Mun Yee Koh, Wee Joo Chng
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Modulation of MicroRNA Expression and Function by ADARs
2011MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by preventing the translation of specific messenger RNAs. Adenosine deaminases acting on RNAs (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing, the conversion of adenosines into inosines, in double-stranded RNAs. Because inosine preferentially base pairs with cytidine,
Kazuko Nishikura, Bjorn-Erik Wulff
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A-to-I RNA editing: The “ADAR” side of human cancer
Seminars in Cell & Developmental Biology, 2012Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human ...
Galeano, Federica +3 more
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The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function
2010From analysis of deep-sequencing data it is apparent that sequence differences occur between the genome and miRNAs. Changes from genomic A to an apparent G in miRNA can be accounted for by the editing activity of ADARs. Questions that arise from this observation are: How many miRNAs are edited and to what frequency?
Liam Keegan +2 more
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CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo
Nature Biotechnology, 2022Philipp Reautschnig +12 more
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