Results 181 to 190 of about 7,998 (203)

From activator to suppressor: PACT is joining the company of PKR negative regulators. [PDF]

RNA
Acosta FM, Pfaller CK.
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

ADAR1 mutation causes ZBP1-dependent immunopathology

Nature, 2022
The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenous double-stranded RNA species1,2. A point mutation in the sequence encoding the Z-DNA-binding domain (ZBD) of ADAR1 is associated with ...
Nicholas W. Hubbard, Joshua M. Ames, Megan Maurano, Lan H. Chu, Kim Y. Somfleth, Nandan S. Gokhale, Margo Werner, Jessica M. Snyder, Katrina Lichauco, Ram Savan, Daniel B. Stetson, Andrew Oberst   +11 more
openaire   +2 more sources

ADAR1 Biology Can Hinder Effective Antiviral RNA Interference

Journal of Virology, 2023
All life at the cellular level has the capacity to induce an antiviral response. Here, we examine the result of imposing the antiviral response of one branch of life onto another and find evidence for conflict.
Skyler Uhl, Chanyong Jang, Justin J. Frere, Tristan X. Jordan, Anne E. Simon, Benjamin R. tenOever   +5 more
openaire   +2 more sources

ADAR1 entraps sinister cellular dsRNAs, thresholding antiviral responses

Trends in Immunology, 2021
ADAR1 edits adenosines to inosines in cellular double-stranded (ds)RNA, thereby preventing aberrant activation of antiviral dsRNA sensors, as well as interferon (IFN) induction in Aicardi-Goutières syndrome (AGS) encephalopathy. Recently, Nakahama et al., Tang et al., Maurano et al., and de Reuver et al.
Liam P. Keegan, Dragana Vukić, Mary A. O’Connell   +2 more
openaire   +2 more sources

CPEB3 suppresses gastric cancer progression by inhibiting ADAR1-mediated RNA editing via localizing ADAR1 mRNA to P bodies

Oncogene, 2022
Deciphering the crosstalk between RNA-binding proteins and corresponding RNAs will provide a better understanding of gastric cancer (GC) progression. The comprehensive bioinformatics study identified cytoplasmic polyadenylation element-binding protein 3 (CPEB3) might play a vital role in GC progression.
Jian Chen, Lu Li, Tian-Yu Liu, Hua-Feng Fu, Yuan-Hui Lai, Xiong Lei, Jun-Fa Xu, Ji-Shang Yu, Yu-Jian Xia, Tian-Hao Zhang, Dong-Jie Yang, Yu-Long He   +11 more
openaire   +2 more sources

ADAR1 Is Essential For Erythroid Development

Blood, 2013
Abstract Understanding the mechanisms controlling erythroid differentiation may allow therapeutic regulation of erythropoiesis. Focus so far has concentrated on the roles of transcription factors in determining erythroid fate, however one mechanism of gene regulation that has been poorly explored is that of direct modification of RNA. It
Brian Liddicoat, Jochen Hartner, Alistair Chalk, Jun Lu, Stuart H. Orkin, Carl R Walkley   +5 more
openaire   +1 more source

SINEs of cancer therapy success without ADAR1

Nature Reviews Molecular Cell Biology, 2020
RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem–loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.
openaire   +2 more sources