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ADAR1 mutation causes ZBP1-dependent immunopathology
Nature, 2022The RNA-editing enzyme ADAR1 is essential for the suppression of innate immune activation and pathology caused by aberrant recognition of self-RNA, a role it carries out by disrupting the duplex structure of endogenous double-stranded RNA species1,2. A point mutation in the sequence encoding the Z-DNA-binding domain (ZBD) of ADAR1 is associated with ...
Nicholas W Hubbard +2 more
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ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
Nature, 2022 The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA)1. In humans, reduced ADAR1 activity causes the severe inflammatory disease Aicardi-Goutières syndrome (AGS)2. In mice, complete loss of ADAR1 activity is embryonically lethal3-6, and mutations similar to
Richard de Reuver +2 more
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SINEs of cancer therapy success without ADAR1
Nature Reviews Molecular Cell Biology, 2020RNA editing by ADAR1 destabilizes epigenetic-treatment-induced retrotransposon stem–loops and thus dampens the immune response to the treatment, suggesting that ADAR1 could be a therapeutic target in combination with epigenetic therapy.
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The anti-apoptotic function of ADAR1 [PDF]
Nature Reviews Molecular Cell Biology, 2017 exaly +2 more sources
ADAR1 Biology Can Hinder Effective Antiviral RNA Interference
Journal of Virology, 2023All life at the cellular level has the capacity to induce an antiviral response. Here, we examine the result of imposing the antiviral response of one branch of life onto another and find evidence for conflict.
Skyler Uhl +5 more
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ADAR1 entraps sinister cellular dsRNAs, thresholding antiviral responses
Trends in Immunology, 2021ADAR1 edits adenosines to inosines in cellular double-stranded (ds)RNA, thereby preventing aberrant activation of antiviral dsRNA sensors, as well as interferon (IFN) induction in Aicardi-Goutières syndrome (AGS) encephalopathy. Recently, Nakahama et al., Tang et al., Maurano et al., and de Reuver et al.
Liam P. Keegan +2 more
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Oncogene, 2022
Deciphering the crosstalk between RNA-binding proteins and corresponding RNAs will provide a better understanding of gastric cancer (GC) progression. The comprehensive bioinformatics study identified cytoplasmic polyadenylation element-binding protein 3 (CPEB3) might play a vital role in GC progression.
Jian Chen +11 more
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Deciphering the crosstalk between RNA-binding proteins and corresponding RNAs will provide a better understanding of gastric cancer (GC) progression. The comprehensive bioinformatics study identified cytoplasmic polyadenylation element-binding protein 3 (CPEB3) might play a vital role in GC progression.
Jian Chen +11 more
openaire +2 more sources
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown [PDF]
Cell, 2018 Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA), is incompletely understood. Mutations in ADAR1, an adenosine-to-inosine editing enzyme of dsRNA, cause Aicardi-Goutières syndrome, an autoinflammatory disorder associated
Hachung Chung, Xianfang Wu, Tony Sun
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