Results 21 to 30 of about 4,347 (166)

RNA editing enzyme ADAR1 is required for early T cell development

Blood Science, 2020
. The RNA editing enzyme ADAR1 has been shown to be an essential molecule for hematopoietic cell differentiation, embryonic development, and regulation of immune responses.
Richard Xufeng, Daibang Nie, Qiong Yang, Wang Wang, Tao Cheng, Qingde Wang   +5 more
doaj   +1 more source

ADAR1 Facilitates HIV-1 Replication in Primary CD4+ T Cells. [PDF]

PLoS ONE, 2015
Unlike resting CD4+ T cells, activated CD4+T cells are highly susceptible to infection of human immunodeficiency virus 1 (HIV-1). HIV-1 infects T cells and macrophages without activating the nucleic acid sensors and the anti-viral type I interferon ...
Eloy Cuadrado, Thijs Booiman, John L van Hamme, Machiel H Jansen, Karel A van Dort, Adeline Vanderver, Gillian I Rice, Yanick J Crow, Neeltje A Kootstra, Taco W Kuijpers   +9 more
doaj   +1 more source

ADAR1 suppression causes interferon signaling and transposable element transcript accumulation in human astrocytes

Frontiers in Molecular Neuroscience, 2023
Neuroinflammation is a central mechanism of brain aging and Alzheimer’s disease (AD), but the exact causes of age- and AD-related neuroinflammation are incompletely understood.
Cali M. McEntee, Cali M. McEntee, Alyssa N. Cavalier, Alyssa N. Cavalier, Thomas J. LaRocca, Thomas J. LaRocca   +5 more
doaj   +1 more source

ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing

Cell Reports, 2023
Summary: Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in which severe inflammation occurs in the brain due to innate immune activation.
Xinfeng Guo, Silvia Liu, Yi Sheng, Mazen Zenati, Timothy Billiar, Alan Herbert, Qingde Wang   +6 more
doaj   +1 more source

IFN-I inducible miR-3614-5p targets ADAR1 isoforms and fine tunes innate immune activation

Frontiers in Immunology, 2022
Regulation of innate immune responses is essential for maintenance of immune homeostasis and development of an appropriate immunity against microbial infection.
Françoise Vuillier, Françoise Vuillier, Zhi Li, Zhi Li, Iain Black, Iain Black, Melania Cruciani, Melania Cruciani, Erminia Rubino, Erminia Rubino, Frédérique Michel, Frédérique Michel, Sandra Pellegrini, Sandra Pellegrini   +13 more
doaj   +1 more source

Ten Novel Mutations of the ADAR1 Gene in Japanese Patients with Dyschromatosis Symmetrica Hereditaria [PDF]

Journal of Investigative Dermatology, 2007
Dyschromatosis symmetrica hereditaria (DSH) is a pigmentary genodermatosis of autosomal-dominant inheritance. We have reported 20 different mutations of the adenosine deaminase acting on RNA 1 gene (ADAR1) in patients with DSH since we had clarified that the disease is caused by a mutation of the ADAR1 gene in 2003.
Suzuki, Noriyuki, Suzuki, Tamio, Inagaki, Katsuhiko, Ito, Shiro, Kono, Michihiro, Horikawa, Tatsuya, Fujiwara, Sakuhei, Ishiko, Akira, Matsunaga, Kayoko, Aoyama, Yumi, Tosaki-Ichikawa, Hiroko, Tomita, Yasushi   +11 more
openaire   +2 more sources

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

eLife, 2017
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss   +9 more
doaj   +1 more source

ADAR1 Function Regulates Innate Immune Activation and Susceptibility to Viral Infections

Proceedings, 2020
Viral infection induces innate intracellular antiviral defenses, aimed at restricting virus replication and spread. Therefore, understanding the role and function of innate immune modulators can help to establish novel strategies for viral control. Here,
Maria Pujantell, Eva Riveira-Muñoz, Edurne García-Vidal, Lucía Gutiérrez-Chamorro, Roger Badia, Bonaventura Clotet, Ester Ballana   +6 more
doaj   +1 more source

An AGS-associated mutation in ADAR1 catalytic domain results in early-onset and MDA5-dependent encephalopathy with IFN pathway activation in the brain

Journal of Neuroinflammation, 2022
Background Aicardi–Goutières syndrome (AGS) is a severe neurodegenerative disease with clinical features of early-onset encephalopathy and progressive loss of intellectual abilities and motor control.
Xinfeng Guo, Richard A. Steinman, Yi Sheng, Guodong Cao, Clayton A. Wiley, Qingde Wang   +5 more
doaj   +1 more source

Host-dependent editing of SARS-CoV-2 in COVID-19 patients

Emerging Microbes and Infections, 2021
A common trait among RNA viruses is their high capability to acquire genetic variability due to viral and host mechanisms. Next-generation sequencing (NGS) analysis enables the deep study of the viral quasispecies in samples from infected individuals. In
Josep Gregori, Maria Francesca Cortese, Maria Piñana, Carolina Campos, Damir Garcia-Cehic, Cristina Andrés, Josep Francesc Abril, Maria Gema Codina, Ariadna Rando, Juliana Esperalba, Elena Sulleiro, Joan Joseph, Narcís Saubí, Sergi Colomer-Castell, Mari Carmen Martin, Carla Castillo, Juan Ignacio Esteban, Tomas Pumarola, Francisco Rodriguez-Frias, Andrés Antón, Josep Quer   +20 more
doaj   +1 more source