Results 31 to 40 of about 4,347 (166)
Scientific Reports, 2023 Triple-negative breast cancer (TNBC) subtype is characterized by aggressive clinical behavior and poor prognosis patient outcomes. Here, we show that ADAR1 is more abundantly expressed in infiltrating breast cancer (BC) tumors than in benign tumors ...
Najat Binothman +14 more
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PLoS Pathogens, 2020 Signaling through retinoic acid inducible gene I (RIG-I) like receptors (RLRs) is tightly regulated, with activation occurring upon sensing of viral nucleic acids, and suppression mediated by negative regulators.
Olivia A Vogel +5 more
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ADAR1 gene mutations in two Chinese pedigrees with dyschromatosis symmetrica hereditaria
International Journal of Dermatology and Venereology, 2023 Introduction: Dyschromatosis symmetrica hereditaria (DSH) is a rare autosomal dominantly inherited disease with high penetrance. Patients with DSH display a mixture of hyperpigmented and hypopigmented macules on the dorsal aspects of the extremities and freckle-like macules on the face.
Ya-Qi Cao, Chun-Yu Han, Jian-Wen Han
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ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway
Life Science Alliance, 2022 Cellular RNA transcripts in endothelial cells, especially the SINE RNAs, need extensive editing by the A-to-I RNA editing enzyme ADAR1, which is essential for neonatal survival by regulating the MDA-5–mediated RNA-sensing signaling pathway.
Xinfeng Guo +6 more
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Genome-wide gene expression array identifies novel genes related to disease severity and excessive daytime sleepiness in patients with obstructive sleep apnea. [PDF]
PLoS ONE, 2017 We aimed to identify novel molecular associations between chronic intermittent hypoxia with re-oxygenation and adverse consequences in obstructive sleep apnea (OSA).
Yung-Che Chen +15 more
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Zα domain proteins mediate the immune response
Frontiers in Immunology, 2023 The Zα domain has a compact α/β architecture containing a three-helix bundle flanked on one side by a twisted antiparallel β sheet. This domain displays a specific affinity for double-stranded nucleic acids that adopt a left-handed helical conformation ...
Yuhan Zhong +6 more
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Journal of Experimental & Clinical Cancer Research, 2022 Background Aberrant RNA editing of adenosine-to-inosine (A-to-I) has been linked to multiple human cancers, but its role in intrahepatic cholangiocarcinoma (iCCA) remains unknown.
Chengming Gao +18 more
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Genetics and Molecular Research, 2013 Dyschromatosis symmetrica hereditaria (DSH) is an autosomal dominant pigmentary genodermatosis, characterized by a mixture of hyperpigmented and hypopigmented macules that are mainly present on the dorsal portions of the extremities. The DSH locus was mapped to chromosome 1q11-q12 and, subsequently, pathogenic mutations in the double-stranded RNA ...
C Y, Zhu, K J, Zhu, Y, Zhou, Y M, Fan
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Tipping the Balance: Antagonism of PKR Kinase and ADAR1 Deaminase Functions by Virus Gene Products [PDF]
Journal of Interferon & Cytokine Research, 2009 The protein kinase regulated by RNA (PKR) and the adenosine deaminase acting on RNA (ADAR1) are interferon-inducible enzymes that play important roles in biologic processes including the antiviral actions of interferons, signal transduction, and apoptosis.
Cyril X, George +5 more
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Differential regulation of aggressive features in melanoma cells by members of the miR-17-92 complex [PDF]
Open Biology, 2014 The various roles of microRNAs (miRNAs) in controlling the phenotype of cancer cells are the focus of contemporary research efforts. We have recently shown that miR-17 directly targets the ADAR1 gene and thereby enhances melanoma cell aggressiveness. miR-
Eyal Greenberg +8 more
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