Results 151 to 160 of about 15,493 (211)
Artificial RNA Editing with ADAR for Gene Therapy
Current Gene Therapy, 2020 Editing mutated genes is a potential way for the treatment of genetic diseases. G-to-A mutations are common in mammals and can be treated by adenosine-to-inosine (A-to-I) editing, a type of substitutional RNA editing. The molecular mechanism of A-to-I editing involves the hydrolytic deamination of adenosine to an inosine base; this reaction is mediated
Sonali Bhakta, Toshifumi Tsukahara
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Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2022 To analyze the clinical features and genetic basis for a Chinese pedigree affected with hereditary dyschromatosis symmetrica hereditaria (DSH).Peripheral blood samples of the proband and his mother were collected and subjected to PCR and Sanger sequencing.The patient has conformed to the typical pattern of DSH and manifested with hyperpigmentation ...
Changyin Wang +6 more
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Current Gene Therapy, 2018 Introduction: Members of the adenosine deaminase acting on RNA (ADAR) family of enzymes consist of double-stranded RNA-binding domains (dsRBDs) and a deaminase domain (DD) that converts adenosine (A) into inosine (I), which acts as guanosine (G) during translation.
Md Thoufic Anam Azad +2 more
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Involvement of PU.1 in mouse adar-1 gene transcription induced by high-dose esiRNA
International Journal of Biological Macromolecules, 2009 Adar-1 gene plays an important role in the negative regulation of RNA interference. We previously showed that increased adar-1 mRNA level was associated with the rebound of gene expression after RNAi suppression. In this study, we identified a PU.1 binding site upstream from transcription start point of adar-1 gene and is essential for the promoter ...
Tongde Wu +4 more
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