Results 231 to 240 of about 176,033 (310)

Biomimetic N‐cyano sulfoximine–thiazole ligation for antibody–drug conjugate assembly

Bulletin of the Korean Chemical Society, EarlyView.
Biomimetic N‐cyano sulfoximine–thiazole ligation is applied for the first time to antibody–drug conjugate assembly. Installation of a sulfoximine handle on trastuzumab followed by ligation with a cysteine‐functionalized payload affords model ADCs with tunable drug‐to‐antibody ratios of 2–8 under mild aqueous conditions.
Eunsil Kim, Ji Ho Song, Na Ryeong Kim, Ji Young Hyun, Ju Yeon Lee, Do Hyun Kang, Hwan Jung Lim, Seong Jun Park   +7 more
wiley   +1 more source

Efficacy and safety of antibody-drug conjugates in EGFR-mutated non-small cell lung cancer after EGFR-TKI resistance: a systematic review and meta-analysis. [PDF]

Front Oncol
Chen Y, Chen S, Zhang H, Xie J, Song B, Xu Y.   +5 more
europepmc   +1 more source

Leveraging HR Analytics Capability for Sustainable Supply Chains: The Roles of Green HRM, AI‐Driven Capabilities and Resource Commitment

Business Strategy and the Environment, EarlyView.
ABSTRACT Among many firms in emerging economies, investments in HR analytics promise strategic insight yet often fail to translate into measurable sustainability gains. This study theorises and tests how HR analytics capability drives supply chain sustainability through the strategic enactment of Green HRM (GHRM).
Philip Opoku Mensah, Emmanuel Mensah Kparl, Abdul‐Razak Suleman, Michael Kyei‐Frimpong, Adam Abdul Mumin, Elias Appiah‐Kubi, Charlotte Adjanor‐Doku   +6 more
wiley   +1 more source

Circulating tumour cells for guiding antibody‒drug conjugate therapy: Role of artificial intelligence. [PDF]

Clin Transl Med
Yaghoubi Naei V, Dabiri M, Chen L, Li J, Wang IH, Lin G, Ebrahimi Warkiani M.   +6 more
europepmc   +1 more source

Development and application of a mechanistic model for protein A resolution of a bispecific antibody for process characterization and optimization

Biotechnology Progress, EarlyView.
Abstract Regeneron's bispecific technology, based on a fully human IgG antibody construct, consists of two distinct heavy chains and a common light chain co‐expressed in a single cell. The co‐expression of the two distinct heavy chains, one of which contains a dipeptide substitution that ablates Protein A binding, leads to the formation of three ...
Samantha Wadsworth, James Reilly, John Mattila, Christopher Cowan, Hanne Bak   +4 more
wiley   +1 more source

A LoRaWAN-Enabled Capacitive Sensor Network for Soil Moisture and Groundwater Monitoring. [PDF]

Sensors (Basel)
Mehdizadeh SA, Moalezadeh JM, Ampatzidis Y.   +2 more
europepmc   +1 more source

Perovskite Photodetectors at the Intelligence Frontier: From Tunable Materials to Adaptive Optoelectronic Systems

Carbon Energy, EarlyView.
This comprehensive review presents a progressive roadmap for perovskite vision detectors. Centered on perovskite‐based artificial perception, the graphic illustrates a systematic evolution: starting with fundamental material engineering and device architectures, advancing toward complex functional strategies such as flexible neuromorphic imaging ...
Chenglong Li, Wei Qu, Deepak Kumar, Naini Jain, Nur Wardina Syahirah binti Mohamad Fadil, Nur Najiha binti Ahmad Rasid, Emannuel Kymakis, Maria Vasilopoulou, Chunxiong Bao, Feng Gao, Peng Gao, Sanjeev Kumar Sharma, Mohammad Khaja Nazeeruddin, Abd. Rashid bin Mohd Yusoff, Haotong Wei   +14 more
wiley   +1 more source

Critical Quality Attribute Investigation and Analytical Method Establishment for Glyco-Site-Specific Anti-HER2 Bispecific ADC. [PDF]

Pharmaceuticals (Basel)
Yu X, Wang L, Cao W, Tang Y, Tang T, Fu Y, Yang Y, Yu C, Li Y, Wang L.   +9 more
europepmc   +1 more source