Results 21 to 30 of about 101,310 (266)
Journal for ImmunoTherapy of Cancer, 2020 Background Regulatory T cells (Tregs) contribute to an immunosuppressive tumor microenvironment. They play an important role in the establishment and progression of tumors with high Tregs infiltration and present a major obstacle to tumor eradication by ...
Francesca Zammarchi +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Dental management of Fanconi anemia: a rare congenital disorder
Journal of Rare DiseasesPurpose Fanconi anemia is a rare inherited genetic disorder that is characterized by all three defective blood cell lines such as reduced red blood cells, platelets, and white blood cells.
Jacqueline Jacinta Dias +2 more
doaj +1 more source
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2021 When designing radio engineering products, at the early stages,one of the most important tasks to be solved is to determine the effective version of the system/device by analyzing all possible available versions.
D. V. Arkhipenkov
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
OncoImmunology, 2019 Oncology treatment has been revolutionized by the introduction of immune checkpoint inhibitor drugs, which enable 20–40% of patients to generate anti-tumor immune responses.
Maxine Bauzon +5 more
doaj +1 more source
Policy Considerations on the Interplay Between State Aid Control and Competition Law
Market and Competition Law Review, 2017 Under the broad topic of the interplay between state aid and competition law, this article addresses the following related lines of discussion: (i) the goals and some of the political rationales of state aid control; (ii) a brief illustration of some of
Maria João Melícias
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Enhanced projectile path estimation using multi-vehicle FMCW radar sensors
Scientific ReportsThis paper presents an enhanced approach to projectile path estimation using Frequency-Modulated Continuous Wave (FMCW) radar sensors distributed across multiple vehicles in a tactical formation.
Amgad A. Salama, Mahmoud A. Hussein
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source