Results 51 to 60 of about 45,428 (223)

Characterization of zolbetuximab in pancreatic cancer models

OncoImmunology, 2019
In healthy tissue, the tight junction protein Claudin 18.2 (CLDN18.2) is present only in the gastric mucosa. Upon malignant transformation of gastric epithelial tissue, perturbations in cell polarity lead to cell surface exposure of CLDN18.2 epitopes ...
Ӧzlem Türeci, Rita Mitnacht-Kraus, Stefan Wöll, Tomohiro Yamada, Ugur Sahin   +4 more
doaj   +1 more source

Metastatic Ceruminous Adenoid Cystic Carcinoma of the Lumbar Spine Causing Neurological Compromise: A Case Report

Geriatric Orthopaedic Surgery & Rehabilitation, 2022
Background Ceruminous glands are modified apocrine glands of the external auditory canal (EAC). Malignant tumours within the ceruminous glands are extremely rare, and the most common histological type is adenoid cystic carcinoma (ADCC), which has high ...
Yi-Wei Shen MD, Yi Yang MD, Hao Liu MD, PhD, Zhong-Jie Zhou MD, Tao Li MD   +4 more
doaj   +1 more source

Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary [PDF]

, 2018
Breast Cancer (BC) skin metastases represent a challenging clinical scenario. Although they usually arise when other distant metastases are already present, they may also represent a form of locoregional recurrence (LRR). Systemic therapy in this setting
Dieci, Maria V, Evangelista, Laura, Giarratano, Tommaso, Giorgi, Carlo A, Guarneri, Valentina, Michieletto, Silvia, Miglietta, Federica, Polico, Ilaria, Tsvetkova, Vassilena   +8 more
core   +1 more source

A variant human IgG1-Fc mediates improved ADCC [PDF]

Protein Engineering, Design and Selection, 2011
Ribosome display was applied to the Fc region of human immunoglobulin G (IgG1) to select for improved binding to human FcγRIIIa, the receptor expressed on human natural killer cells that mediates antibody-dependent cellular cytotoxicity (ADCC). A library of human Fcγ1 variants was generated using error-prone polymerase chain reaction, and subjected to ...
Ross, Stewart, George, Thom, Michaela, Levens, Gülin, Güler-Gane, Robert, Holgate, Pauline M, Rudd, Carl, Webster, Lutz, Jermutus, John, Lund   +8 more
openaire   +2 more sources

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

OncoImmunology, 2019
Here we describe a novel bifunctional fusion protein, designated N-809. This molecule comprises the IL-15/IL15Rα superagonist complex containing the Fc-domain of IgG1 (N-803, formerly designated as ALT-803) fused to two single chain anti-PD-L1 domains ...
Caroline Jochems, Sarah R. Tritsch, Karin M. Knudson, Sofia R. Gameiro, Claire Smalley Rumfield, Samuel T. Pellom, Y. Maurice Morillon, Robby Newman, Warren Marcus, Christopher Szeto, Shahrooz Rabizadeh, Hing C. Wong, Patrick Soon-Shiong, Jeffrey Schlom   +13 more
doaj   +1 more source

Antibody-dependent cellular cytotoxicity targeting CD4-inducible epitopes predicts mortality in HIV-infected infantsResearch in context

EBioMedicine, 2019
Background: Antibody-dependent cellular cytotoxicity (ADCC) has been associated with improved infant outcome in mother-to-child transmission (MTCT) of HIV-1. Epitopes of these ADCC-mediating antibodies remain unidentified.
Nicole E. Naiman, Jennifer Slyker, Barbra A. Richardson, Grace John-Stewart, Ruth Nduati, Julie M. Overbaugh   +5 more
doaj   +1 more source

Comprehensive Cytomorphologic Analysis of Pulmonary Adenoid Cystic Carcinoma: Comparison to Small Cell Carcinoma and Non-pulmonary Adenoid Cystic Carcinoma [PDF]

Journal of Pathology and Translational Medicine, 2015
Background: Cytologic diagnosis of pulmonary adenoid cystic carcinoma (AdCC) is frequently challenging and differential diagnosis with small cell carcinoma is often difficult. Methods: Eleven cytologically diagnosed cases of pulmonary AdCC were collected
Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han   +3 more
doaj   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

The Early Antibody-Dependent Cell-Mediated Cytotoxicity Response Is Associated With Lower Viral Set Point in Individuals With Primary HIV Infection

Frontiers in Immunology, 2018
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an immune response largely mediated by natural killer (NK) cells that can lyse target cells and combat tumors and viral infections.
Xi Chen, Xi Chen, Xi Chen, Xi Chen, Meilin Lin, Meilin Lin, Meilin Lin, Meilin Lin, Meilin Lin, Shi Qian, Shi Qian, Shi Qian, Shi Qian, Zining Zhang, Zining Zhang, Zining Zhang, Zining Zhang, Yajing Fu, Yajing Fu, Yajing Fu, Yajing Fu, Junjie Xu, Junjie Xu, Junjie Xu, Junjie Xu, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han, Xiaoxu Han, Haibo Ding, Haibo Ding, Haibo Ding, Haibo Ding, Tao Dong, Hong Shang, Hong Shang, Hong Shang, Hong Shang, Yongjun Jiang, Yongjun Jiang, Yongjun Jiang, Yongjun Jiang   +41 more
doaj   +1 more source