Results 211 to 220 of about 32,310 (305)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Design of efficient binary multiplier architecture using hybrid compressor with FPGA implementation. [PDF]

Sci Rep
Thamizharasan V, Parthipan V.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Clinical features of puff adder envenoming: case series of Bitis arietans snakebites in Kenya and a scoping review of the literature. [PDF]

PLoS Negl Trop Dis
Tianyi FL, Ngari C, Wilkinson M, Parkurito S, Chebet E, Mumo E, Trelfa A, Otundo D, Crittenden E, Kephah GM, Harrison RA, Stienstra Y, Casewell NR, Lalloo DG, Oluoch GO.   +14 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

All-electrical recursive generation and time-domain mode division multiplexing of Hermite-Gaussian pulses for optical, THz and RF links. [PDF]

Sci Rep
Yu X, Meier J, Mandal P, Hosni MI, Venugopalan A, Wang L, Schneider T.   +6 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Quantifying venom in African snakes: Insights into protein content, yield and body size associations. [PDF]

Toxicon X
French S, Da Silva R, Have MT, Crittenden E, Rowley P, Cullen IC, Holland Z, Wilkinson MC, Modahl CM.   +8 more
europepmc   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A Photo-Patternable Solid-State Electrolyte for High-Performance, Miniaturized, and Implantable Organic Electrochemical Transistor-Based Circuits. [PDF]

Adv Mater
Xiong M, Yang CY, Ji J, Caravaca AS, Guo Q, Li Q, Donahue MJ, Gao D, Wu HY, Marks A, Xu Y, Tu D, McCulloch I, Olofsson PS, Fabiano S.   +14 more
europepmc   +1 more source