Results 111 to 120 of about 361,512 (315)

Whole genome amplification of sodium bisulfite-treated DNA allows the accurate estimate of methylated cytosine density in limited DNA resources

BioTechniques, 2006
Sodium bisulfite modification-based fine mapping of methylated cytosines represents the gold standard technique for DNA methylation studies. A major problem with this approach, however, is that it results in considerable DNA degradation, and large ...
Jonathan Mill, Simin Yazdanpanah, Eva Gückel, Sigrid Ziegler, Zachary Kaminsky, Arturas Petronis   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Addiction and Self-Control: An Intrapersonal Game [PDF]

In their model of addiction, O´Donoghue and Rabin obtain a counterintuitive result: a person that is fully aware of his self-control problems (sophisticate) is more prone to become addicted than one who is fully naware (na¨ıf).
López Rafael
core  

Contextualising over-engagement in work: towards a more global understanding of workaholism as an addiction [PDF]

, 2012
Purpose: Despite increasing empirical research into workaholism, no single definition or conceptualisation has emerged, and current understandings of workaholism are arguably problematic.
Karanika-Murray, Maria, Griffiths, Mark D., Griffiths, MD, Mark D. Griffiths, Karanika-Murray, M, Maria Karanika-Murray   +5 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Care considerations in medical assistance in dying for persons with mental illness as the sole underlying medical condition: a qualitative study of patient and family perspectives

BMC Psychiatry
Background Persons with mental illness as their sole underlying medical condition are eligible to access medical assistance in dying (MAiD) in a small number of countries, including Belgium, the Netherlands, Luxemburg and Switzerland.
Vicky Stergiopoulos, Hamer Bastidas-Bilbao, Mona Gupta, Daniel Z. Buchman, Donna E. Stewart, Tarek Rajji, Alexander I. F. Simpson, Mary Rose van Kesteren, Vivien Cappe, David Castle, Roslyn Shields, Lisa D. Hawke   +11 more
doaj   +1 more source

The Addicted Brain [PDF]

Frontiers in Psychiatry, 2013
Classification of behavioral disturbances should be done by carefully considering the boundaries between physiology (normality) and pathology (disease), irrespective of social context. The following considerations will highlight some of the objectivable changes observed in the brains of animals and humans who underwent repetitive use of addicting ...
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

“Inclusivity requires an active effort”: building an inclusive and diverse space when engaging people with lived and living experience and caregivers in mental health and substance use health research

Research Involvement and Engagement
Background Engaging people with lived/living experience and caregivers (PLLEX-C) in mental health and substance use health research has many advantages for scientists, research staff, and PLLEX-C.
Abigail Amartey, Shoshana Hauer, Charlotte Munro, Claudia Sendanyoye, Katie Upham, Mary Rose van Kesteren, Tanya Halsall, Yona Lunsky, Lisa D. Hawke   +8 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source