Results 41 to 50 of about 48,821 (256)

Potential of D-cycloserine in the treatment of behavioral and neuroinflammatory disorders in Parkinson's disease and studies that need to be performed before clinical trials

Kaohsiung Journal of Medical Sciences, 2012
Hyperactivation of glutamatergic N-methyl-D-aspartate (NMDA) receptors has been implicated in the excitotoxicity and pathophysiology of Parkinson's disease (PD).
Cornelius Rainer Pawlak, Fu-Shih Chen, Fu-Ying Wu, Ying-Jui Ho   +3 more
doaj   +1 more source

Changes of consultation-liaison psychiatry practice in Italian general hospitals: A comparative 20-year multicenter study

Frontiers in Psychiatry, 2022
IntroductionConducted under the auspices of the Italian Society of Consultation Liaison Psychiatry (SIPC) the aim of this study was to describe the characteristics of Consultation Liaison Psychiatry (CLP) activity in Italy (SIPC-2—2018) over the past 20 ...
Luigi Zerbinati, Luigi Zerbinati, Laura Palagini, Laura Palagini, Matteo Balestrieri, Martino Belvederi Murri, Martino Belvederi Murri, Rosangela Caruso, Rosangela Caruso, Armando D’Agostino, Armando D’Agostino, Maria Ferrara, Maria Ferrara, Silvia Ferrari, Silvia Ferrari, Antonino Minervino, Paolo Milia, Maria Giulia Nanni, Maria Giulia Nanni, Stefano Pini, Pierluigi Politi, Matteo Porcellana, Matteo Rocchetti, Ines Taddei, Tommaso Toffanin, Tommaso Toffanin, Luigi Grassi, Luigi Grassi, Italian Society of Consultation-Liaison Psychiatry, Jessica Bellucci, Jessica Bellucci, Emilio Bergamelli, Victor Attilio Campagna, Melissa Cherubini, Melissa Cherubini, Federica Folesani, Federica Folesani, Marta Gancitano, Marta Gancitano, Francesca Giannetti, Gianluca Giovanna, Benedetta Gullotta, Benedetta Gullotta, Lucia Massa, Giulia Montardi, Giulia Montardi   +45 more
doaj   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Introduction to Behavioral Addictions [PDF]

The American Journal of Drug and Alcohol Abuse, 2010
Several behaviors, besides psychoactive substance ingestion, produce short-term reward that may engender persistent behavior, despite knowledge of adverse consequences, i.e., diminished control over the behavior. These disorders have historically been conceptualized in several ways. One view posits these disorders as lying along an impulsive-compulsive
Jon E, Grant, Marc N, Potenza, Aviv, Weinstein, David A, Gorelick   +3 more
openaire   +2 more sources

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, EarlyView.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Types and Forms of Addictive Behavior of Law Enforcement Employees

Психология и право, 2019
The article discusses types and forms of an addictive behavior of law enforcement officers (in terms of employees of internal affairs bodies) in conjunction with individual psychological characteristics.
Chernyshova E.V., Suslova V.R.
doaj   +1 more source

Multifactor Risk Stratification for Post‐Transplant Alcohol Relapse Using Abstinence, Psychosocial, and Socioeconomic Factors

Annals of Gastroenterological Surgery, EarlyView.
Alcohol relapse after liver transplantation is difficult to predict using abstinence duration alone. We developed a multifactor model integrating abstinence duration, psychosocial risk (SIPAT), and socioeconomic context (AUC 0.70). This approach may support individualized risk assessment and tailored follow‐up intensity; external validation is needed ...
Ayato Obana, Garren Montgomery, Miho Akabane, Matthew Hamilton, Navdeep Singh, Musab Alebrahim, Austin Schenk, Sylvester Black, Kenneth Washburn, Khalid Mumtaz   +9 more
wiley   +1 more source

Peningkatan Self Compassion Untuk Mereduksi Perilaku Adiktif Pengguna Sosial Media Bagi Siswa SMP

Indonesian Journal of Learning Education and Counseling, 2020
The research aims to describe the process of counseling services on improving self-compassion of students in Surabaya Private Junior High Schools who have problems with addictive behaviors using sophisticated technology especially the social media ...
Agus Rizal, Budi Purwoko, Retno Tri Hariastuti   +2 more
doaj   +1 more source