Results 61 to 70 of about 5,779,386 (384)

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Investigation of the combined effects of cannabidiol plus naltrexone on alcohol craving in alcohol dependence: study protocol of a phase II randomised, double-blind, placebo-controlled, parallel-group trial – ICONICplus Trial

BMJ Open
Introduction Alcohol dependence (AD) is highly prevalent and has severe consequences on health and quality of life. However, the efficacy of approved pharmacotherapies such as naltrexone (NTX) remains limited, highlighting the need for novel ...
Falk Kiefer, Christina Klose, Bettina C Thomas, Sabine Vollstaedt-Klein, Marietta Kirchner, Anne Koopmann, Bernd Lenz, Patrick Bach, Sina Vetter, Julia Weinberg, Paul Thalmann, Marlen Pfisterer, Torsten Kölsch, Selma Oesterle, Tobias Link   +14 more
doaj   +1 more source

Addiction, compulsion, and weakness of the will: A dual process perspective [PDF]

, 2016
How should addictive behavior be explained? In terms of neurobiological illness and compulsion, or as a choice made freely, even rationally, in the face of harmful social or psychological circumstances?
Henden, Edmund
core  

Delta Opioid Receptors within the Cortico‐Thalamic Circuitry Underlie Hyperactivity Induced by High‐Dose Morphine

Advanced Science, EarlyView.
Morphine activates the excitatory cingulate cortex–intermediate rostrocaudal division of zona incerta (Cg‐ZIm) pathway to drive hyperlocomotion in mice. Inhibiting the Cg‐ZIm pathway attenuates both acute and chronic morphine‐induced hyperlocomotion, while its activation mimics morphine's motor effects.
Chun‐Yue Li, Huiqian Huang, Xiao‐Fan Shen, Ke‐Lei Cao, Di Zheng, Yi Zhu, Shi‐Ze Xie, Xiao‐Dan Yu, Hao Wang, Jia‐Dong Chen, Jie Shi, Yue Li, Min Yan, Xiao‐Ming Li   +13 more
wiley   +1 more source

An exploration into “do-it-yourself” (DIY) e-liquid mixing: Users' motivations, practices and product laboratory analysis

Addictive Behaviors Reports, 2019
Background: E-liquids are commercially available and manufactured, however some users of e-cigarettes prefer to prepare them at home (Do-it-Yourself; DIY) using individual ingredients.
Sharon Cox, Noel J. Leigh, Taylor S. Vanderbush, Emma Choo, Maciej L. Goniewicz, Lynne Dawkins   +5 more
doaj   +1 more source

Cortical Glutamate and GABA Changes During Early Abstinence in Alcohol Dependence and Their Associations With Benzodiazepine Medication

Frontiers in Psychiatry, 2021
In this report, we present cross-sectional and longitudinal findings from single-voxel MEGA-PRESS MRS of GABA as well as Glu, and Glu + glutamine (Glx) concentrations in the ACC of treatment-seeking alcohol-dependent patients (ADPs) during detoxification
Guoying Wang, Wolfgang Weber-Fahr, Ulrich Frischknecht, Ulrich Frischknecht, Derik Hermann, Derik Hermann, Falk Kiefer, Gabriele Ende, Markus Sack   +8 more
doaj   +1 more source

Investigando la relación entre el autocontrol, la edad y el desajuste psicológico en adolescentes y jóvenes adultos españoles [PDF]

, 2019
Este estudio explora las tendencias evolutivas en el autocontrol y su relación con el desajuste psicológico en adolescentes y jóvenes adultos. La muestra estuvo compuesta por 1,600 adolescentes y jóvenes adultos españoles de entre 12 y 34 años (M = 22.28,
Antolín Suárez, Lucía, Oliva Delgado, Alfredo, Rodríguez Meirinhos, Ana   +2 more
core   +3 more sources

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Potential of D-cycloserine in the treatment of behavioral and neuroinflammatory disorders in Parkinson's disease and studies that need to be performed before clinical trials

Kaohsiung Journal of Medical Sciences, 2012
Hyperactivation of glutamatergic N-methyl-D-aspartate (NMDA) receptors has been implicated in the excitotoxicity and pathophysiology of Parkinson's disease (PD).
Cornelius Rainer Pawlak, Fu-Shih Chen, Fu-Ying Wu, Ying-Jui Ho   +3 more
doaj   +1 more source

Changes of consultation-liaison psychiatry practice in Italian general hospitals: A comparative 20-year multicenter study

Frontiers in Psychiatry, 2022
IntroductionConducted under the auspices of the Italian Society of Consultation Liaison Psychiatry (SIPC) the aim of this study was to describe the characteristics of Consultation Liaison Psychiatry (CLP) activity in Italy (SIPC-2—2018) over the past 20 ...
Luigi Zerbinati, Luigi Zerbinati, Laura Palagini, Laura Palagini, Matteo Balestrieri, Martino Belvederi Murri, Martino Belvederi Murri, Rosangela Caruso, Rosangela Caruso, Armando D’Agostino, Armando D’Agostino, Maria Ferrara, Maria Ferrara, Silvia Ferrari, Silvia Ferrari, Antonino Minervino, Paolo Milia, Maria Giulia Nanni, Maria Giulia Nanni, Stefano Pini, Pierluigi Politi, Matteo Porcellana, Matteo Rocchetti, Ines Taddei, Tommaso Toffanin, Tommaso Toffanin, Luigi Grassi, Luigi Grassi, Italian Society of Consultation-Liaison Psychiatry, Jessica Bellucci, Jessica Bellucci, Emilio Bergamelli, Victor Attilio Campagna, Melissa Cherubini, Melissa Cherubini, Federica Folesani, Federica Folesani, Marta Gancitano, Marta Gancitano, Francesca Giannetti, Gianluca Giovanna, Benedetta Gullotta, Benedetta Gullotta, Lucia Massa, Giulia Montardi, Giulia Montardi   +45 more
doaj   +1 more source