Results 31 to 40 of about 9,677,556 (313)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reversible addition fragmentation chain transfer (RAFT) polymerization : mechanism, process and applications

, 2012
The present article gives an overview of the reversible addition fragmentation chain transfer (RAFT) process. RAFT is one of the most versatile living radical polymerization systems and yields polymers of predictable chain length and narrow molecular ...
Christopher Barner-Kowollik, James P. Blinco, Mathias Destarac, Barner, Leonie, Destarac, Mathias, Sébastien Perrier, Perrier, Sebastien, Blinco, James P., Thurecht, Kristofer, Kristofer J. Thurecht   +9 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Addition-Isomerization Polymerization of Chiral Phosphaalkenes: Observation of Styrene–Phosphaalkene Linkages in a Random Copolymer

, 2016
These studies provide the first evidence for styrene–phosphaalkene connectivities in a phosphaalkene copolymer. The synthesis and structural characterization of new phosphaalkene–oxazolines, ArPC­(Ph)­(3-C6H4Ox) [1a,b, Ar = Mes (1a), Mes* (1b), Ox ...
Spencer C. Serin (1701490), Gregory R. Dake (1701493), Derek P. Gates (1701487)   +2 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Reversible addition fragmentation chain transfer polymerization of 3-[tris(trimethylsilyloxy) silyl] propyl methacrylate

, 2003
Reversible addition fragmentation chain transfer (RAFT) bulk polymerizations of 3-[tris(trimethylsilyloxy)silyl] propyl methacrylate (TRIS) have been carried out at 60°C, employing cumyl dithiobenzoate (CDB) and 2-cyanoprop-2-yl dithiobenzoate (CPDB) as ...
Heuts, J. P. A., Davis, T. P., Saricilar, S, Knott, R, Barner-Kowollik, C, Knott, R., Saricilar, S., Davis, TP, Heuts, JPA, Barner-Kowollik, C.   +9 more
core   +1 more source

Fully degradable polymer networks from conventional radical polymerization of vinyl monomers enabled by thionolactone addition

, 2022
We report the preparation of degradable polymer networks by conventional free radical copolymerization of n-butyl acrylate with a crosslinker (1 mol%) and dibenzo[c,e]oxepane-5-thione (DOT) as a strand-cleaving comonomer.
Nathaniel, Bingham, Harry, Elliss, Peter , Roth, Maciej, Kopeć, Frances, Dawson, Qamar, un Nisa   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Electrochemically Mediated Reversible Addition–Fragmentation Chain-Transfer Polymerization

Macromolecules, 2017
An electrochemically mediated reversible addition-fragmentation chain-transfer polymerization (eRAFT) of (meth)acrylates was successfully carried out via electroreduction of either benzoyl peroxide (BPO) or 4-bromobenzenediazonium tetrafluoroborate ...
Yi Wang, Marco Fantin, Sangwoo Park, Eric R Gottlieb, Liye Fu, K. Matyjaszewski   +5 more
semanticscholar   +1 more source