Results 91 to 100 of about 128,882 (238)

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

A novel process for tailored stiffness and strength in extrusion based additive manufacturing [PDF]

, 2017
Extrusion based additive manufacturing (AM) techniques have gained interest and were continuously developed during the last quarter-century. However, the currently integrated processes have their limitations in different aspects.
Cardon, Ludwig, Ragaert, Kim, Van De Steene, Willem   +2 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

First Approach in Analysis of Tool Wear When Milling Additive Manufacturing (AM) Parts

Applied Sciences
Wire arc additive manufacturing (WAAM) and laser-based powder bed fusion (L-PBF) are additive manufacturing (AM) processes that allow the manufacturing of complex part geometries.
Konstantin Sommer, Anja Pfennig, Fiona Sammler, Mahmoud Abdelmoula, Denis Kamerer, Roland Heiler   +5 more
doaj   +1 more source

Toward better build volume packing in additive manufacturing: classification of existing problems and benchmarks [PDF]

, 2015
In many cases, the efficient operation of Additive Manufacturing (AM) technology relies on build volumes being packed effectively. Packing algorithms have been developed in response to this requirement.
Araujo, L.J.P., Atkin, Jason, Baumers, Martin, Hague, Richard J.M., Tuck, Christopher, Özcan, Ender   +5 more
core  

Optimisation of surface measurement for metal additive manufacturing using coherence scanning interferometry [PDF]

, 2017
Surface topography measurement for metal additive manufacturing (AM) is a challenging task for contact and non-contact methods. In this paper, we present an experimental investigation of the use of coherence scanning interferometry (CSI) for measurement ...
Adam Thompson, Artigas, Carlos Gomez, Fay, Fay, Gibson, Giusca, Gu, Helmli, Jack DiSciacca, Kiselev, Leach, Leach, Leach, Leach, Leach, Petzing, Richard Leach, Rong Su, Roth, Schmidt, Schmit, Simon Lawes, Taylor   +23 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

ADDITIVE MANUFACTURING FOR SUSTAINABLE CUSTOM-DESIGNED IMPLANTS

South African Journal of Industrial Engineering, 2019
Additive manufacturing (AM) has proven to be an attractive alternative manufacturing process compared with subtractive manufacturing (SM). Additive manufacturing has many advantages, such as mass customisation, less material wastage, and others listed in
Booysen, G. J. , van der Merwe, A. F. , de Beer, D. J.   +2 more
doaj   +1 more source

Benefits and costs of additive manufacturing applications: an evaluation guideline [PDF]

, 2015
With an ever growing diffusion of additive manufacturing (AM) system in industrial and consumer level, as well as the direct and indirect dynamics which are being introduced resulting from its inclusion as a viable production system on companies ...
Ashour Pour, Milad, Bacchetti, Andrea, Zanardini, Massimo, Zanoni, Simone   +3 more
core