Results 101 to 110 of about 33,834 (307)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Integrating Additive Manufacturing Techniques to Improve Cell-Based Implants for the Treatment of Type 1 Diabetes. [PDF]

Adv Healthc Mater, 2022
Accolla RP, Simmons AM, Stabler CL.
europepmc   +1 more source

Recent Advances in 3D Printing and Additive Manufacturing Technology

Additive manufacturing (AM) or 3D printing has played a critical role in Industry 4 [...
Thang Q. Tran
core   +1 more source

A rapid design exploration framework under additive manufacturing process uncertainty

, 2018
Current computer-aided design (CAD) systems are not computationally efficient for exploring the growing design space of products manufactured with additive manufacturing (AM). A rapid method with sufficient fidelity is desired. Meanwhile, uncertainties
Xiong, Yi, Duong, Pham Luu Trung, Raghavan, Nagarajan, Rosen, David W   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Laser induced hydrophobicity on the TI6AL4V additive manufacturing parts

, 2018
The widespread adoption of additive manufacturing (AM) is always challenged by the quality of the AM part. In the current context many efforts are focusing on the internal quality such as porosity, mechanical properties and dimensional accuracy but not
Moon, Seung Ki, Jiao, Lishi
core   +1 more source

Integrated design-oriented framework for Resource Selection in Additive Manufacturing [PDF]

, 2018
Resource selection (RS) is one of the prime phases of product design that have substantiating impact on the manufacturing of products. Material and manufacturing process selection are considered an important ingredient of RS and must be dealt with in ...
Uzair Khaleeq uz Zaman, Ali Siadat, SIADAT, Ali, Mickael Rivette, Aamer Ahmed Baqai, UZ ZAMAN, Uzair Khaleeq, BAQAI, Aamer Ahmed, RIVETTE, Mickaël   +7 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The analogies between human development and additive manufacture: Expanding the definition of design

Cogent Engineering, 2019
Design techniques represent a huge economic barrier to the progression of Additive Manufacturing (AM) to more industrial applications. The aim of this research is to use biological analogies, taken from human development to offer a new perspective on ...
L. E. J. Thomas-Seale, J. C. Kirkman-Brown, S. Kanagalingam, M. M. Attallah, D. M. Espino, D. E. T. Shepherd   +5 more
doaj   +1 more source