Results 101 to 110 of about 142,725 (307)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Benefits and costs of additive manufacturing applications: an evaluation guideline [PDF]

, 2015
With an ever growing diffusion of additive manufacturing (AM) system in industrial and consumer level, as well as the direct and indirect dynamics which are being introduced resulting from its inclusion as a viable production system on companies ...
Ashour Pour, Milad, Bacchetti, Andrea, Zanardini, Massimo, Zanoni, Simone   +3 more
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Applications of additive manufacturing (AM) in sustainable energy generation and battle against COVID-19 pandemic: The knowledge evolution of 3D printing. [PDF]

J Manuf Syst, 2021
Wang Y, Ahmed A, Azam A, Bing D, Shan Z, Zhang Z, Tariq MK, Sultana J, Mushtaq RT, Mehboob A, Xiaohu C, Rehman M.   +11 more
europepmc   +1 more source

Embracing additive manufacture: implications for foot and ankle orthosis design [PDF]

, 2012
Background The design of foot and ankle orthoses is currently limited by the methods used to fabricate the devices, particularly in terms of geometric freedom and potential to include innovative new features.
A Salles, AK Ramanathan, C Anderson, C Mavroidis, DG Smith, DJ Bregman, DJ Bregman, E Sells, ES Schrank, GN Levy, HB Menz, Jari Pallari, Javier Munguia, JHP Pallari, Jim Woodburn, K Postema, Kenny Dalgarno, Martin McGeough, MC Faustini, MM Lusardi, RA Zifchock, RDF Mason, S Fatone, S Telfer, SA Radtka, Scott Telfer, T Kobayashi, T Wohlers   +27 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Integrating Additive Manufacturing Techniques to Improve Cell-Based Implants for the Treatment of Type 1 Diabetes. [PDF]

Adv Healthc Mater, 2022
Accolla RP, Simmons AM, Stabler CL.
europepmc   +1 more source

Porous composite with negative thermal expansion obtained by photopolymer additive manufacturing

, 2015
Additive manufacturing (AM) could be a novel method of fabricating composite and porous materials having various effective performances based on mechanisms of their internal geometries.
Kitamura, Mitsuru, Kobashi, Makoto, Takezawa, Akihiro   +2 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Nondestructive Evaluation of Additive Manufacturing State-of-the-Discipline Report [PDF]

This report summarizes the National Aeronautics and Space Administrations (NASA) state of the art of nondestructive evaluation (NDE) for additive manufacturing (AM), or "3-D printed", hardware.
Burke, Eric R., Hodges, Kenneth L., Parker, Bradford H., Walker, James L., Waller, Jess M.   +4 more
core   +1 more source