Results 91 to 100 of about 33,834 (307)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

First Approach in Analysis of Tool Wear When Milling Additive Manufacturing (AM) Parts

Applied Sciences
Wire arc additive manufacturing (WAAM) and laser-based powder bed fusion (L-PBF) are additive manufacturing (AM) processes that allow the manufacturing of complex part geometries.
Konstantin Sommer, Anja Pfennig, Fiona Sammler, Mahmoud Abdelmoula, Denis Kamerer, Roland Heiler   +5 more
doaj   +1 more source

Titanium Alloy Fabricated by Additive Manufacturing for Medical Applications: Obtaining, Characterization and Application—Review

, 2023
Metal additive manufacturing (metal-AM) technology has made significant progress in the field of biomedicine in recent years. Originally, it was only used as an innovative resource for prototypes.
Shuai Liu, Yude Liu, Wentian Shi, Hanjie Guo, Xinjie Zhang   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ADDITIVE MANUFACTURING FOR SUSTAINABLE CUSTOM-DESIGNED IMPLANTS

South African Journal of Industrial Engineering, 2019
Additive manufacturing (AM) has proven to be an attractive alternative manufacturing process compared with subtractive manufacturing (SM). Additive manufacturing has many advantages, such as mass customisation, less material wastage, and others listed in
Booysen, G. J. , van der Merwe, A. F. , de Beer, D. J.   +2 more
doaj   +1 more source

Structural Integrity of Polymeric Components Produced by Additive Manufacturing (AM)-Polymer Applications. [PDF]

Polymers (Basel), 2021
Martins RF, Branco R, Berto F, Soares N, Bandeira S.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Applications of additive manufacturing (AM) in sustainable energy generation and battle against COVID-19 pandemic: The knowledge evolution of 3D printing. [PDF]

J Manuf Syst, 2021
Wang Y, Ahmed A, Azam A, Bing D, Shan Z, Zhang Z, Tariq MK, Sultana J, Mushtaq RT, Mehboob A, Xiaohu C, Rehman M.   +11 more
europepmc   +1 more source

Opportunities and Limitations of Additive Manufacturing

, 2023
Additive manufacturing (AM) is a terminology synonymous with 3D printing of materials for recreational purposes and more importantly for specialized applications in industry.
Alifui-Segbaya, Frank, Gupta, Ankit, Fidan, Ismail, Ituarte, Iñigo Flores, Hasanov, Seymur   +4 more
core   +1 more source