Results 81 to 90 of about 33,834 (307)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Additive manufacturing of Invar 36 alloy
Journal of Materials Research and TechnologyInvar 36 alloy, renowned for its ultra-low coefficient of thermal expansion (CTE), is a functional Fe–Ni alloy that finds wide applications in aerospace and precision instruments. Additive manufacturing (AM), as a rapid digital manufacturing process, can
Guoliang Huang +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Fast Desktop-Scale Extrusion Additive Manufacturing
, 2019 Significant improvements to the throughput of additive manufacturing (AM) processes are essential to their cost-effectiveness and competitiveness with traditional processing routes.
Go, Jamison, Hart, Anastasios John
core +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
International Journal of Lightweight Materials and ManufactureAdditive Manufacturing (AM) technology is recognized as a pivotal direction for future technological and industrial advancement. Nevertheless, inherent to the manufacturing process are defects such as pores, inclusions, lack of fusion, and layering ...
Huan Xi +3 more
doaj +1 more source
Additive Manufacturing: Prospects and Diverse Applications
Additive manufacturing (AM), also known as 3D printing, has emerged as a transformative technology in various industries, providing unprecedented design freedom and customized manufacturing solutions.
Zeyuan Li +6 more
core +1 more source
Machine learning in additive manufacturing: State-of-the-art and perspectives
, 2020 Additive manufacturing (AM) has emerged as a disruptive digital manufacturing technology. However, its broad adoption in industry is still hindered by high entry barriers of design for additive manufacturing (DfAM), limited materials library, various ...
Lim, C.S. +7 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source