Results 81 to 90 of about 142,725 (307)
The Impact of Additive Manufacturing Technologies on Industrial Spare Parts Strategies [PDF]
, 2018 The paper aims to investigate potential benefits and the applicability of additive manufacturing (AM) technologies for spare parts management in the automotive industry.
Beiderbeck, Daniel +2 more
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Additive manufacturing of Invar 36 alloy
Journal of Materials Research and TechnologyInvar 36 alloy, renowned for its ultra-low coefficient of thermal expansion (CTE), is a functional Fe–Ni alloy that finds wide applications in aerospace and precision instruments. Additive manufacturing (AM), as a rapid digital manufacturing process, can
Guoliang Huang +5 more
doaj +1 more source
Comparison of Different Additive Manufacturing Methods Using Optimized Computed Tomography [PDF]
, 2016 Additive manufacturing (AM) allows for fast fabrication of three dimensional objects with the possibility of use of considerably less resources than would be the case in traditional manufacturing.
Bills, Paul J. +2 more
core
An additive manufacturing filter for topology optimization of print-ready designs [PDF]
, 2016 Additive manufacturing (AM) offers exciting opportunities to manufacture parts of unprecedented complexity. Topology optimization is essential to fully exploit this capability. However, AM processes have specific limitations as well.
Matthijs Langelaar
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Towards Fully Additively-Manufactured Permanent Magnet Synchronous Machines: Opportunities and Challenges [PDF]
, 2019 With the growing interest in electrification and as hybrid and pure electric powertrains are adopted in more applications, electrical machine design is facing challenges in terms of meeting very demanding performance metrics for example high specific ...
EL-Refaie, Ayman M., Wu, Fan
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source