Results 111 to 120 of about 128,882 (238)

Materials Characterization of Additively Manufactured Components for Rocket Propulsion [PDF]

To advance Additive Manufacturing (AM) technologies for production of rocket propulsion components the NASA Glenn Research Center (GRC) is applying state of the art characterization techniques to interrogate microstructure and mechanical properties of AM
Carter, Robert, Cooper, Ken, Draper, Susan, Ellis, David, Free, James, Jones, Zachary, Lerch, Bradley, Locci, Ivan, Meyer, Michael, Senick, Paul   +9 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Production of syndiotactic polystyrene powder for part manufacturing through SLS [PDF]

, 2014
Selective laser sintering (SLS) is a well-established additive manufacturing (AM) process. While AM originally found its use as rapid prototyping technique, it is nowadays more and more considered for the production of actual end-use parts.
Cardon, Ludwig, Haverans, Tom, Mys, Nicolas, Verberckmoes, An   +3 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Investigation of microstructure and hardness of a rib geometry produced by metal forming and wire-arc additive manufacturing

MATEC Web of Conferences, 2018
Within the scope of consumer-oriented production, individuality and cost-effectiveness are two essential aspects, which can barely be met by traditional manufacturing technologies. Conventional metal forming techniques are suitable for large batch sizes.
Hirtler Markus, Jedynak Angelika, Sydow Benjamin, Sviridov Alexander, Bambach Markus   +4 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Additive manufacturing in biomedical: Applications, challenges, and prospects

Hybrid Advances
Additive Manufacturing (AM), also called 3D printing, has introduced revolutionary advancements across multiple industries, particularly impacting the biomedical field.
Md Hosne Mobarak, Abu Sofian Abid, Md Shahriar Munna, Mihir Dutta, Md Israfil Hossain Rimon   +4 more
doaj   +1 more source

Investigation on Additive Manufacturing as an enabler for reshoring manufacturing activities [PDF]

The recent phenomenon known as re-shoring, has gained momentum among developed countries. It is also evident that the new generation of technologies such as Additive Manufacturing (AM) and intelligent robotics can affect the manufacturing location ...
Backhouse, Chris J., Moradlou, Hamid, Mountney, Sara, Sawhney, Rapinder   +3 more
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Advancing Sustainable Decision Making in Additive Manufacturing: A Comprehensive Review of Multi-Criteria Decision Making Approaches

Clean Technologies
Additive manufacturing (AM) is one of the technologies of Industry 4.0 that has been contributing to the development of different manufacturing industries.
Adriana S. F. Alves, J. P. Oliveira, Radu Godina   +2 more
doaj   +1 more source