Results 91 to 100 of about 15,909 (257)

Advancements in Metal Processing Additive Technologies: Selective Laser Melting (SLM) [PDF]

Nowadays, the use of metal processing additive technologies is a rapidly growing field in the manufacturing industry. These technologies, such as metal 3D printing (also known as additive manufacturing) and laser cladding, allow for the production of ...
Paola Leo, Gilda Renna, Neetesh Soni
core   +1 more source

Advancing laser powder bed fusion of metals via tailored laser beam shaping: A critical review

Materials & Design
Laser beam shaping is increasingly explored to enhance Laser Powder Bed Fusion of Metals (PBF-LB/M) by controlling the spatial energy distribution within the laser spot.
Abid Ullah, Kashif Azher, Tingting Liu, Philipp Kohlwes, Dirk Herzog, Reshad Bakhtari, Alexander E. Medvedev, Asif Ur Rehman, Kai Zhang, Andrey Molotnikov, Ingomar Kelbassa, Milan Brandt   +11 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Gait Pattern Generator for Closed-Loop Position Control of a Soft Walking Robot

Frontiers in Robotics and AI, 2020
This paper presents an approach to control the position of a gecko-inspired soft robot in Cartesian space. By formulating constraints under the assumption of constant curvature, the joint space of the robot is reduced in its dimension from nine to two ...
Lars Schiller, Arthur Seibel, Josef Schlattmann   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Comparative Studies of the Properties of Copper Components: Conventional vs. Additive Manufacturing Technologies [PDF]

This article presents a comparative analysis of the crucial physical properties of electrically conductive components made of pure copper, produced by various additive manufacturing technologies such as binder jetting (BJ) and direct metal laser ...
Joanna Kulasa, Anna Brudny, Bartlomiej Adamczyk, Witold Malec, Ryszard Rzepecki, Andrzej Rybak, Anna Hury, Robert Sekula, Grzegorz Kmita   +8 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

CVD-Engineered Nano Carbon Architectures: Mechanisms, Challenges, and Outlook

Nanomaterials
Graphitic nanomaterials have emerged as foundational components in nanoscience owing to their exceptional electrical, mechanical, and chemical properties, which can be tuned by controlling dimensionality and structural order.
Maria Hasan, Szymon Abrahamczyk, Muhammad Aashir Awan, Ondřej Sakreida, Alicja Bachmatiuk, Grazyna Simha Martynková, Karla Čech Barabaszová, Mark Hermann Rümmeli   +7 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source