Results 91 to 100 of about 6,934,820 (306)
Non-metallic additive manufacturing technology has seen a substantial improvement in the precision of the parts it produces. Its capability to achieve complex geometries and very small dimensions makes it suitable for integration into strategic ...
Salguero Gómez, Jorge +7 more
core +1 more source
Heterogeneous Material Additive Manufacturing for Hot-Stamping Die
, 2020 Additive manufacturing (AM) has recently been receiving global attention. As an innovative alternative to existing manufacturing technologies, AM can produce three-dimensional objects from various materials.
Woo-Sung Kim +6 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Additive manufacturing and high performance applications
, 2018 The requirement on life and robustness for aero-engine components poses obstacles to additive manufacturing. It is expected that increasing knowledge about the process and thereby its development together with adaption of existing alloys may improve ...
Lindgren, Lars-Erik, +3 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Emerging Trends in Hybrid Additive and Subtractive Manufacturing
The great capability of additive manufacturing to produce parts with complex, even impossible to achieve, geometries through five-or-more-axis machining or other conventional processes opened a promising future decades ago.
Manuel Ángel Rabalo +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Recent Advances in 3D Printing and Additive Manufacturing Technology
Additive manufacturing (AM) or 3D printing has played a critical role in Industry 4 [...
Thang Q. Tran
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Upper limb prostheses face acceptance challenges due to factors such as discomfort, limited functionality, high weight, and elevated costs. Despite the availability of advanced models with sophisticated technologies, their accessibility remains limited ...
Rodrigo Cézar da Silveira Romero +3 more
core +1 more source