Results 91 to 100 of about 156,720 (303)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Generation of patterned indentations for additive manufacturing technologies
IISE Transactions, 2018 This article proposes a novel approach to generate patterned indentations for different additive manufacturing methodologies.
Ulas Yaman +2 more
openaire +2 more sources
Rapid manufacturing- state of the art, analysis and future perspectives [PDF]
, 2011 Layer based manufacturing system often referred to as Rapid Prototyping (RP) have been in existence for 22 years, in the past 5 years Rapid Manufacturing (RM) has emerged from these RP systems to produce functional and structural customer focused end use
Ainsley, Christopher, Hackney, Philip
core
A Design Method to Exploit Synergies Between Fiber-Reinforce Composites and Additive Manufactured Processes [PDF]
, 2019 This paper proposes a design method for devices composed of long fiber-reinforced composites (FRC) and additive manufactured (AM) parts. Both FRC and AM processes have similar application characteristics: suitable for small production volumes, additive ...
Ethan Goh +4 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Current options in the life cycle assessment of additive manufacturing products
Open Engineering, 2019 Additive manufacturing (AM) is a manufacturing process that allows for the creation of a physical object from a digital model. Additive manufacturing has a number of advantages over the conventional methods, inter alia the production of very complex ...
Výtisk Jan +3 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Embracing additive manufacture: implications for foot and ankle orthosis design [PDF]
, 2012 Background The design of foot and ankle orthoses is currently limited by the methods used to fabricate the devices, particularly in terms of geometric freedom and potential to include innovative new features.
A Salles +27 more
core +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Multi-disciplinary approach in engineering education: learning with additive manufacturing and reverse engineering [PDF]
, 2015 Purpose - The purpose of this paper is to report an interdisciplinary, cooperative-learning project in a second-year course within the "Enzo Ferrari" Master of Science Degree in Mechanical Engineering.
Bassoli, Elena +4 more
core +1 more source