Results 81 to 90 of about 6,934,820 (306)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Analysis of the wall geometry with different strategies for high deposition wire arc additive manufacturing of mild steel [PDF]

, 2020
Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.Additive manufacturing has gained relevance in recent decades as an alternative to the manufacture of metal parts. Among the additive technologies, those that are classified as
Lamikiz, Aitzol, Aitzol Lamikiz, Bilbao, Jon, Eider Aldalur, Fernando Veiga, Suárez, Alfredo, Veiga Suárez, Fernando, Jon Bilbao, Aldalur, Eider, Lamikiz Mentxaka, Aitzol, Veiga, Fernando, Suárez González, Alfredo, Alfredo Suárez   +12 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

ADDITIVE MANUFACTURING OF ARCHITECTED INCONEL 718 STRUCTURES: EXPLORING THE STRENGTH AND FAILURE OF LATTICE STRUCTURES

Materiali in Tehnologije
This study investigates the mechanical performance and failure behaviour of additively manufactured Inconel 718 (IN718) lattice structures fabricated via laser powder bed fusion (PBF-LB).
Sami Westman, Ahmed Abdelghany, Mahmoud Khedr, Lari Rajala, Ilkka Poutiainen, Antti Järvenpää   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

EFFECTS OF LASER POWER, SCAN SPEED AND HEAT TREATMENT ON MICROSTRUCTURE AND HARDNESS OF PBF-LB INCONEL 718

Materiali in Tehnologije
This study quantifies the effects of laser power and scan speed on the aged microstructure and hardness of PBF-LB Inconel 718 processed under the EOS-standard heat-treatment schedule.
Ahmed Abdelghany, Matias Jaskari, Sami Westman, Ilkka Poutiainen, Antti Järvenpää   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Additive Manufacturing: Prospects and Diverse Applications

Additive manufacturing (AM), also known as 3D printing, has emerged as a transformative technology in various industries, providing unprecedented design freedom and customized manufacturing solutions.
Zeyuan Li, Minghao Li, Hulong Ruan, Junjun Wang, Lina Chen, Qixing Jia, Chenglong Yu   +6 more
core   +1 more source

Advancing laser powder bed fusion of metals via tailored laser beam shaping: A critical review

Materials & Design
Laser beam shaping is increasingly explored to enhance Laser Powder Bed Fusion of Metals (PBF-LB/M) by controlling the spatial energy distribution within the laser spot.
Abid Ullah, Kashif Azher, Tingting Liu, Philipp Kohlwes, Dirk Herzog, Reshad Bakhtari, Alexander E. Medvedev, Asif Ur Rehman, Kai Zhang, Andrey Molotnikov, Ingomar Kelbassa, Milan Brandt   +11 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source