Results 71 to 80 of about 6,934,820 (306)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Multi-axis infrared process monitoring with contextual machine learning for inspecting build-condition in laser directed energy deposition

JPhys Photonics
As the production of additive manufacturing (AM) metal parts for service-ready and performance-critical components increases, verification of part quality is becoming an increasingly essential stage of the manufacturing pipeline.
Timothy Herzog, Milan Brandt, Ruwan Tennakoon, Andrey Molotnikov   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Functionally graded additive manufacturing

, 2021
Functionally graded additive manufacturing (FGAM) is a layer-by-layer manufacturing technique that allows material composition and organization to be achieved within a single volume to enable variational functionalities.
Godec, Damir, Nordin, Axel, University, Brunel, Gonzalez-Gutierrez, Joamin, Godec, Damir,, Gonzalez-Gutierrez, Joamin,, Nordin, Axel,, University, Brunel,, Pei, Eujin, Pei, Eujin,, Lund University.   +10 more
core   +1 more source

Achieving high strength and ductility in Inconel 718: tailoring grain structure through micron-sized carbide additives in PBF-LB/M additive manufacturing

Virtual and Physical Prototyping
Few attempts have been made so far to develop modifiers for in situ use in Inconel 718 PBF-LB/M fabrication. Reports show an increase in tensile strength compared to unmodified counterparts.
Konrad Gruber, Wojciech Stopyra, Karol Kobiela, Philipp Kohlwes, Jan Čapek, Efthymios Polatidis, Ingomar Kelbassa   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Engineering Tomorrow: Optimised Materials and Surfaces for Additive Manufacturing

Focusing on advancements in additive manufacturing, this Special Issue explores the role of novel materials and surface technologies in improving functionality, performance, and sustainability.
Tomislav Cigula, Marina Vukoje, Raša Urbas   +2 more
core   +1 more source

Systematic study of the interplay between laser beam shape, energy input, and hatch spacing in PBF-LB/M of Ti-6Al-4V: experiments and numerical modeling

Materials & Design
Programmable laser beam shaping tailors the spatial irradiance distribution in laser powder bed fusion (PBF-LB/M), enabling control over melt-pool geometry and defect formation.
Abid Ullah, Reshad Bakhtari, Jan Johannsen, Philipp Kohlwes, Kai Zhang, Tingting Liu, Amjad Iqbal, Dirk Herzog, Alexander E. Medvedev, Andrey Molotnikov, Ingomar Kelbassa, Milan Brandt   +11 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Cyber-Physically controlled Smart Additive Manufacturing system (CPSAM) : Plenary speech

, 2021
This plenary presentation is focused on the coming manufacturing systems for metal additive manufacturing controlled cyber-physically. Cyber-Physically controlled Smart Additive Manufacturing system (CPSAM) is a smart additive manufacturing system for ...
Asnafi, Nader,, Stroud, Ian, Suh, Suk-Hwan,   +2 more
core