Results 61 to 70 of about 15,909 (257)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Buckingham-Pi dimensionless analysis for melt pool stability and defect prediction in additive manufacturing

Additive Manufacturing Letters
Melt pool instabilities limit the reliability of additive manufacturing. Here, we demonstrate that a minimal Buckingham-π framework, supplemented by a normalized enthalpy (NE) metric, consolidates process outcomes across heat source settings (power ...
Mahdi Alishavandi, Rahmi Ünal, Metin U. Salamci   +2 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Assessment of the Development Performance of Additive Manufacturing VPP Parts Using Digital Light Processing (DLP) and Liquid Crystal Display (LCD) Technologies [PDF]

Non-metallic additive manufacturing technology has seen a substantial improvement in the precision of the parts it produces. Its capability to achieve complex geometries and very small dimensions makes it suitable for integration into strategic ...
Salguero Gómez, Jorge, Vázquez Martínez, Juan Manuel, Mora Jiménez, Jairo, Jorge Salguero, Batista Ponce, Moisés, Moises Batista, Jairo Mora-Jimenez, Juan Manuel Vazquez-Martinez   +7 more
core   +1 more source

Additive manufacturing and its effect on sustainable design [PDF]

, 2016
'Sustainability' is an emerging issue that product development engineers must engage with to remain relevant, competitive and, most importantly, responsible.
Kristav, Per,, Diegel, Olaf,, Motte, Damien,, Lund University., Kianian, Babak,   +4 more
core   +1 more source

Fundamental investigation on the impact of Cu powder oxidation states on processability by powder bed Fusion-Laser Beam/Metal (PBF-LB/M)

Materials & Design
This study introduces targeted oxidation of Cu powders as a strategy to improve both laser power coupling and powder reusability for the PBF-LB/M process.
Arne Röttger, Jonas Hankel, Robert Ortmann, Eric Schneider, Fabienne Hellwig, Milli Suchita Kujur, Tobias Grimm, Christian Sternemann, Jan T. Sehrt   +8 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Emerging Trends in Hybrid Additive and Subtractive Manufacturing [PDF]

The great capability of additive manufacturing to produce parts with complex, even impossible to achieve, geometries through five-or-more-axis machining or other conventional processes opened a promising future decades ago.
Manuel Ángel Rabalo, Amabel García, Eva María Rubio   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Recent Advances in 3D Printing and Additive Manufacturing Technology [PDF]

Additive manufacturing (AM) or 3D printing has played a critical role in Industry 4 [...
Thang Q. Tran
core   +1 more source