Results 101 to 110 of about 6,934,820 (306)

Additive manufacturing as a platform for introducing cyber-physical services

, 2018
Additive manufacturing (AM) is increasingly used for the production of functional components. This process is based on digital design model and can produce customized components with no additional cost (toolless process).
Holmström, Jan, Khajavi, Siavash H., Baumers, Martin   +2 more
core   +1 more source

CVD-Engineered Nano Carbon Architectures: Mechanisms, Challenges, and Outlook

Nanomaterials
Graphitic nanomaterials have emerged as foundational components in nanoscience owing to their exceptional electrical, mechanical, and chemical properties, which can be tuned by controlling dimensionality and structural order.
Maria Hasan, Szymon Abrahamczyk, Muhammad Aashir Awan, Ondřej Sakreida, Alicja Bachmatiuk, Grazyna Simha Martynková, Karla Čech Barabaszová, Mark Hermann Rümmeli   +7 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Review of Additive Manufacturing Techniques in Artificial Reef Construction: Materials, Processes, and Ecological Impact

In recent years, additive manufacturing technologies have been employed for ecological projects, especially those connected with artificial reefs. This approach brings a lot of advantages, including the design of more complex structures, with surfaces ...
Wei-Ting Lin, Kinga Korniejenko, Anna Źróbek, Kacper Oliwa, Szymon Gądek, Piotr Dynowski   +5 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Use of Machine Learning to Improve Additive Manufacturing Processes

Rapidly developing artificial intelligence (AI) can help machines and devices to perceive, analyze, and even make inferences in a similar way to human reasoning. The aim of this article is to present applications of AI methods, including machine learning
Izabela Rojek, Jakub Lewandowski, Dariusz Mikołajewski, Jakub Kopowski   +3 more
core   +1 more source

Additive manufacturing and its effect on sustainable design

, 2016
'Sustainability' is an emerging issue that product development engineers must engage with to remain relevant, competitive and, most importantly, responsible.
Kristav, Per,, Diegel, Olaf,, Motte, Damien,, Lund University., Kianian, Babak,   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Research progress and application of additive manufacturing technology for rotorcraft structure

Cailiao gongcheng
The rotorcraft structures have typical characteristics such as small batches， multi-specifications， complex shape and high-performance requirements. Additive manufacturing technologies have the ability to integrally form complex shapes and structures and
HAN Zhenzhong, CHEN Guangchang, LI Wei, HE Peigang, WEN Peigang, YE Shuqun, LIANG Kun, DENG Xudong   +7 more
doaj   +1 more source