Results 101 to 110 of about 15,909 (257)

Research progress and application of additive manufacturing technology for rotorcraft structure

Cailiao gongcheng
The rotorcraft structures have typical characteristics such as small batches， multi-specifications， complex shape and high-performance requirements. Additive manufacturing technologies have the ability to integrally form complex shapes and structures and
HAN Zhenzhong, CHEN Guangchang, LI Wei, HE Peigang, WEN Peigang, YE Shuqun, LIANG Kun, DENG Xudong   +7 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A Comparative Analysis of the Additive Manufacturing Alternatives for Producing Steel Parts [PDF]

Companies are increasingly turning to additive manufacturing as the demand for one-off 3D-printed metal parts rises. The differences in available additive manufacturing technologies necessitate considering both cost and externalities to select the most ...
Pourya Pourhejazy, Wei Deng Solvang, Mathias Sæterbø   +2 more
core   +1 more source

Infusing Additive Manufacturing Education with Applications: An Industry-Centric Approach [PDF]

, 2014
This paper details how Nanyang Polytechnic has applied industry-centric approach in training its students and industry personnel with relevant additive manufacturing technologies infused with real industry applications.
David S. K. Wong, Wong, David S. K.
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Integrated design-oriented framework for Resource Selection in Additive Manufacturing [PDF]

, 2018
Resource selection (RS) is one of the prime phases of product design that have substantiating impact on the manufacturing of products. Material and manufacturing process selection are considered an important ingredient of RS and must be dealt with in ...
Uzair Khaleeq uz Zaman, Ali Siadat, SIADAT, Ali, Mickael Rivette, Aamer Ahmed Baqai, UZ ZAMAN, Uzair Khaleeq, BAQAI, Aamer Ahmed, RIVETTE, Mickaël   +7 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Design for Additive Manufacturing : Supporting Intrinsic-Motivated Creativity [PDF]

, 2017
Emotional aspects and designers’ motivations in Design For Additive Manufacturing are rarely studied. Still, as they can influence creative behaviors, it is worth of interest to draw some bases for a relation between designers’ motivations and the field ...
VAYRE, Benjamin, ABED, Stéphane, Stéphane Abed, Carole Bouchard, SEGONDS, Frederic, BOUCHARD, Carole, Frédéric Segonds, Benjamin Vayre, RIAS, Anne Lise, Anne-lise Rias   +9 more
core   +1 more source

The Possibilities of Additive Manufacturing in Medical Use

International Journal of Engineering and Management Sciences, 2019
Additive Manufacturing has been invented in 1981 at the University of Texas, and to this day it has grown to be the most versatile and promising manufacturing technology in the market, both the industry and health care system has noticed this.
Dániel Szabó
doaj   +1 more source