Results 121 to 130 of about 15,909 (257)

Progress in Powder Based Additive Manufacturing [PDF]

This open access book presents 12 years of cutting-edge research on additive manufacturing (AM), with a focus on innovative powder- and beam-based techniques.

core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Quasi-Uniform Density Non-Solid Infill Strategy for Axisymmetric Non-Planar Additive Manufacturing [PDF]

Non-solid infill generation in Non-Planar Additive Manufacturing (NPAM) is still an open problem. This is due to mathematical complexities from curvature distortion, as well as bridging limitations inherent in some NPAM processes.
Francisco J. Badesa, Ramiro García-Galán, Elio Sanchez-Oro-Aguado, Antonio Vizan-Idoipe, Alvaro Guzman-Bautista, Adrián López-Arrabal, Andrea Fernández Gorgojo   +6 more
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Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Microstructure Characteristics and Mechanical Properties of High-Strength Invar Alloy by Wire Arc Additive Manufacturing [PDF]

Wire arc additive manufacturing (WAAM) is a viable technology for manufacturing complex and medium-to-large-sized invar alloy components. However, the cyclic thermal input during the WAAM process may cause the austenite grains in the component to grow ...
Jun He, Hongxin Zhang, Cuixin Chen, Weibing Guo, Chenyu Zhao, Haitao Xue, Caidong Zhang, Zhonghua Sun, Baoxi Liu   +8 more
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Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comparing Technologies of Additive Manufacturing for the Development of Modular Dosimetry Phantoms in Radiation Therapy [PDF]

, 2020
In radiotherapy, X-ray imaging and dose quality assurance is often carried out using physical phantoms, which simulate the X-ray attenuation of biological tissue.
Krause, Dieter, Wegner, Marie, Spallek, Johanna, Gargioni, Elisabetta   +3 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Corrosion in laser powder bed fusion AlSi10Mg alloy

Engineering Reports
Aluminum alloy AlSi10Mg is a widely used engineering material that offers a very high strength‐to‐weight ratio and easy processing. It is common in the aerospace, medical, and automotive industries and has excellent machining and casting properties, as ...
Hossein Laieghi, Varma Kvvssn, Muhammad Muteeb Butt, Peyman Ansari, Metin U. Salamci, Albert E. Patterson, Elmas Salamci   +6 more
doaj   +1 more source