Results 141 to 150 of about 6,934,820 (306)
Hybrid design based on wire and arc additive manufacturing in the aircraft industry [PDF]
, 2012 Wire and Arc Additive Manufacturing (WAAM) is a developing rapid prototyping and manufacturing technology which allows the production of large custom-made metal parts with high deposition rates, a major concern of the aircraft industry.
Chen, Jian
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Additive Manufacturing Group at Naval Postgraduate School [PDF]
, 2016 Several departments are collaborating as the Additive Manufacturing Group; MOVES Institute, Mechanical and Aerospace Engineering, Energy Academic Group, Space Systems Academic Group and Center for Asymmetric Warfare.
Sadagic, Amela, Brutzman, Don
core +1 more source
Effects of Two Melt Extrusion Based Additive Manufacturing Technologies and Common Sterilization Methods on the Properties of a Medical Grade PLGA Copolymer. [PDF]
Polymers (Basel), 2021 Gradwohl M +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
A Comparative Analysis of the Additive Manufacturing Alternatives for Producing Steel Parts
Companies are increasingly turning to additive manufacturing as the demand for one-off 3D-printed metal parts rises. The differences in available additive manufacturing technologies necessitate considering both cost and externalities to select the most ...
Pourya Pourhejazy +2 more
core +1 more source
Corrosion in laser powder bed fusion AlSi10Mg alloy
Engineering ReportsAluminum alloy AlSi10Mg is a widely used engineering material that offers a very high strength‐to‐weight ratio and easy processing. It is common in the aerospace, medical, and automotive industries and has excellent machining and casting properties, as ...
Hossein Laieghi +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source