Results 91 to 100 of about 4,105,512 (288)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Quantifying the sensitivity of maize production to long-term trends in fertilization and regional climate in China

Journal of Agriculture and Food Research
The regional climate over China has changed pronouncedly since the mid-20th, posing substantial risks and uncertainties to local crop production. The maize production has demonstrated considerable sensitivity to such changes. Observations in recent years
Na Huang, Ju Liang, Fei Lun, Kang Jiang, Buju Long, Xiao Chen, Riping Gao, Yi Zhou, Jingyu Men, Pengshuai Bi, Zhihua Pan   +10 more
doaj   +1 more source

مستقبل الحاسبات الالكترونية في التعليم

Iraqi Journal for Computers and Informatics, 1981
نتائج بحث لتقييم أداء بعض أساليب تنظيم المعلومات للوصول المباشر باستعمال العنونة التحتية (Hach Addressing) من خلال تطبيقها على ملفات نموذجية للمفاتيح Sample Keys Files) تم اختيارها من الواقع التطبيقي لأنظمة مهمة في قطرنا .
ندى عبد علي
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

اساليب الوصول المباشر لملفات نموذجية من واقع القطر مع التركيز على استعمال الاسماء العربية كمفاتيح

Iraqi Journal for Computers and Informatics, 1982
نتائج بحث لتقييم أداء بعض أساليب تنظيم المعلومات للوصول المباشر باستعمال العنونة التحتية (Hach Addressing) من خلال تطبيقها على ملفات نموذجية للمفاتيح Sample Keys Files) تم اختيارها من الواقع التطبيقي لأنظمة مهمة في قطرنا .
ندى عبد علي
doaj   +1 more source

Addressing Ambiguity in Multi-target Tracking by Hierarchical Strategy

, 2017
This paper presents a novel hierarchical approach for the simultaneous tracking of multiple targets in a video. We use a network flow approach to link detections in low-level and tracklets in high-level.
Liu, Liu, Qi, Hairong, Taalimi, Ali
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Fostering an Atmosphere of Professionalism in a Residency Program: Learning How to Address the Unprofessional Behavior of Colleagues Through OSCEs

MedEdPORTAL, 2012
Introduction Professionalism training and assessment have received much attention. Multiple strategies have been devised to help educational programs deal with unprofessional behavior, which is not always detected by attending staff.
Lita Aeder, Lisa Altshuler, Elizabeth Kachur, Erik Langenau   +3 more
doaj   +1 more source

Addressing Function Approximation Error in Actor-Critic Methods [PDF]

, 2018
In value-based reinforcement learning methods such as deep Q-learning, function approximation errors are known to lead to overestimated value estimates and suboptimal policies.
Fujimoto, Scott, Meger, David, van Hoof, Herke   +2 more
core   +1 more source