Results 61 to 70 of about 4,105,512 (288)

Design of scalable metalens array for optical addressing

open access: yesFrontiers of Optoelectronics, 2022
Large-scale trapped-ion quantum computers hold great promise to outperform classical computers and are crucially desirable for finance, pharmaceutical industry, fundamental chemistry and other fields.
Tie Hu   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Addressing Exercise Education in Clinton County, NY [PDF]

open access: yes, 2018
In Clinton County, NY residents state that obesity, chronic disease, physical inactivity and low wages are top concerns. Many of these identified problems are tightly integrated and exacerbated by a lack of exercise education in this population.
Kardys, Amanda M
core   +1 more source

Individual-Ion Addressing with Microwave Field Gradients

open access: yes, 2012
Individual-qubit addressing is a prerequisite for many instances of quantum information processing. We demonstrate this capability on trapped-ion qubits with microwave near-fields delivered by electrode structures integrated into a microfabricated ...
Colombe, Y.   +5 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Addressing nutritional literacy in preschool learning environments [PDF]

open access: yes, 2017
INTRODUCTION: Obesity among preschool children is more common among lower-income families. Prevalence of type 2 diabetes in U.S. Mexican and African American populations has steadily increased and is associated with modifiable risk factors, such as poor ...
Warren, Cynthia
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Interfaces of Contemporary Poetry: Turn-taking and Multiple Addressing

open access: yesСлово.ру: балтийский акцент
The characteristic feature of contemporary poetry is an increased attention to the prag­matics of the message. The Internet influences the activation of the communication function, and metalinguistic reflection in poetry manifests itself through the ...
Zakharkiv E.V.
doaj   +1 more source

How Do I Address You? Modelling addressing behavior based on an analysis of a multi-modal corpora of conversational discourse [PDF]

open access: yes, 2008
Addressing is a special kind of referring and thus principles of multi-modal referring expression generation will also be basic for generation of address terms and addressing gestures for conversational agents.
Akker, Rieks op den, Theune, Mariët
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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