Isoketals form cytotoxic phosphatidylethanolamine adducts in cells
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are γ-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts.
C. Blake Sullivan +4 more
doaj +1 more source
A Canine Musculoskeletal Robot for Investigating Biomechanical Functions During Locomotion
In this study, a dog limb musculoskeletal robot was developed using thin McKibben artificial muscles to investigate the effects of the dog's musculoskeletal structure on walking. Walking experiments were conducted in both indoor and outdoor environments, suggesting that the flexible structure of the dog's shoulders contributes to an increase in stroke ...
Hana Ito +6 more
wiley +1 more source
The reaction of acyclic enaminones with methoxymethylene Meldrum's acid afforded N-adduct and/or C-adduct of enaminones in moderate to good yields. The regiochemistry of this reaction depends on the N-amino substituent of the enaminone. The C-adduct is a
Cunha Silvio +4 more
doaj
Citation: 'σ-adduct' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.A05436 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire +1 more source
Synthesis, X-ray Structures, Electronic Properties, and O\u3csub\u3e2\u3c/sub\u3e/NO Reactivities of Thiol Dioxygenase Active-Site Models [PDF]
Mononuclear non-heme iron complexes that serve as structural and functional mimics of the thiol dioxygenases (TDOs), cysteine dioxygenase (CDO) and cysteamine dioxygenase (ADO), have been prepared and characterized with crystallographic, spectroscopic ...
Brunold, Thomas C. +4 more
core +1 more source
Polyaspers A and B, the First
Hong Hu +12 more
openalex +1 more source
Harnessing Carbenoid Reactivity From Imidazoles and Oxiranes
The combination of azole compounds and oxiranes exhibits carbenoid reactivity at elevated temperatures, as demonstrated by the successful benzoin condensation of aromatic aldehydes. Using this catalytic system to polymerize bifunctional aldehyde/oxirane monomers yields thermosets with glass transition temperatures above 100°C.
Matthias R. Steiner +4 more
wiley +1 more source
REGIOSPECIFIC SYNTHESIS OF 1,6- DIMETHY L-9,lO-ANTHRACENEDIONE [PDF]
Treatment of acetyl- 1,4-benzoquinone with isoprene gave the corresponding regioselective adduct (I). Rearrangement of the adduct (1) in pyridine and methanol gave 2-acetyl-5, 8-dihydro-6-methyl- 1,4-dihydroxynaphthalene (2).
doaj
Missing value imputation for LC-MS metabolomics data by incorporating metabolic network and adduct ion relations [PDF]
Zhuxuan Jin, Jian Kang, Tianwei Yu
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Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source

