Results 111 to 120 of about 198,348 (348)

Three‐Component Synthesis of γ‐Amino Esters with α‐Quaternary Carbon Centers via NHC/Photoredox Dual Catalysis

Advanced Synthesis &Catalysis, EarlyView.
γ‐Amino acid derivatives with an α‐quaternary center are prevalent in medicinally important compounds. A dual N‐heterocyclic carbene/photocatalytic pathway is developed for the three‐component synthesis of α, α ‐disubstituted γ‐amino esters. This methodology allows for the rapid synthesis of diverse libraries of γ‐amino esters in good yields.
Adam X. Wayment, Karl A. Scheidt
wiley   +1 more source

The structure of Chlamydomonas LOV1 as revealed by time-resolved serial synchrotron crystallography

IUCrJ
The photo-reaction of the LOV1 domain of the Chlamydomonas reinhardtii phototropin is investigated by room-temperature time-resolved serial crystallography. A covalent adduct forms between the C4a atom of the central flavin-mononucleotide chromophore and
Marius Schmidt
doaj   +1 more source

An ESR Study of 1:1 Adducts of Bis-salicylaldehyde-imine-cobalt(II) Complexes with Oxygen in Solutions [PDF]

, 1969
Akira Misono, Seiichiro Koda
openalex   +1 more source

Electrochemical Chemo‐ and Regioselective Heterofunctionalization of Tropones via C(sp2)H Derivatization

Advanced Synthesis &Catalysis, EarlyView.
Simple and selective. The electrochemical heterofunctionalization of activated tropones is achieved using readily available inorganic salts. A theoretical model, based on cyclic voltammetry and quantum chemistry calculations, predicts both reactivity trends and site selectivity.
Mauro Garbini, Samuele Moncullo, Sofia Kiriakidi, Manuela Melucci, Sara Bellini, Chiara Zanardi, Carlos Silva López, Giulio Bertuzzi, Marco Bandini   +8 more
wiley   +1 more source

Reaction of Proton Pump Inhibitors With Model Peptides Results in Novel Products

Journal of Pharmacological Sciences, 2013
The proposed mechanism for proton pump inhibitors (PPIs) is that PPIs are activated at low pH to the sulfenamide form, which reacts with the sulfhydryl group of cysteine(s) at the active site of the proton pump, to produce reducible disulfide-bonded PPI ...
Charles Watson, Lixin Zhu, Shenheng Guan, Terry E. Machen, John G. Forte   +4 more
doaj  

The Synergistic Effect in Solvent Extraction. The Effect of the Chelating Ligands on the Stability Constant of Lutetium β-Diketonate Adducts with TOPO [PDF]

, 1969
Takaharu Honjyo
openalex   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

Infrared spectra of adducts of tetrasulfur tetranitride with metal halides [PDF]

, 1969
P. J. Ashley, E. G. Torrible
openalex   +1 more source

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Hydride hydrogen-exchange between organotin and -lead compounds: Formation of organolead hydride adducts [PDF]

, 1966
H.M.J.C. Creemers, A.J. Leusink, J. G. NOLTES, G. J. M. van der Kerk   +3 more
openalex   +1 more source