Results 141 to 150 of about 198,348 (348)

THE THERMAL REVERSIBILITY OF THE MICHAEL REACTION: III. 1,5-DIKETONES AND ADDUCTS BEARING ACIDIC GROUPS [PDF]

, 1964
C. F. H. Allen, G. P. Happ
openalex   +1 more source

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

Advanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao, Xianping Liu, Xu Chu, Feixiang Chen, Ruicheng Shi, Zonghao Liu, Yelin Wu, Yanyan Liu, Wenbo Bu   +8 more
wiley   +1 more source

Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells

Journal of Lipid Research, 1994
Lipid-derived free radicals were detected by electron paramagnetic resonance (EPR) spectrometry when cultured endothelial cells attached to Cytodex beads were exposed to iron-induced oxidant stress in the presence of the spin trap alpha-(4-pyridyl-1 ...
L S Alexander-North, J A North, K P Kiminyo, G R Buettner, A A Spector   +4 more
doaj  

Manganese‐Catalyzed Electrochemical Diazidation of Dehydroalanine Peptides

Advanced Science, EarlyView.
A Mn(II)‐catalyzed electrochemical method achieves site‐selective diazidation of dehydroalanine peptides with NaN₃. This radical relay process tolerates diverse functional groups, delivers high yields, and enables precise peptide modification, offering a powerful tool for bioconjugation and therapeutic development.
Xinwei Hu, Chengwei Zheng, Xiaotong Song, Balati Hasimujiang, Mu Chen, Zhixiong Ruan   +5 more
wiley   +1 more source

Isoketals form cytotoxic phosphatidylethanolamine adducts in cells

Journal of Lipid Research, 2010
Levuglandins and their stereo- and regio-isomers (termed isolevuglandins or isoketals) are γ-ketoaldehydes (IsoK) that rapidly react with lysines to form stable protein adducts.
C. Blake Sullivan, Elena Matafonova, L. Jackson Roberts, II, Venkataraman Amarnath, Sean S. Davies   +4 more
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Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity

Advanced Science, EarlyView.
This study introduces a mild photocatalytic strategy for synthesizing tunable α‐sulfide disulfides from readily available sulfides and bilateral disulfurating reagents. The method demonstrates a broad substrate scope across aromatic and aliphatic sulfides, with products exhibiting versatile reactivity in diverse electrophilic transformations and ...
Qingqiang Tian, Chuxia Wang, Bingrui Liu, Xiangwei Wu, Yahui Li   +4 more
wiley   +1 more source

Decomposition of a phosphoryl azide adduct of norbornylene [PDF]

, 1968
Robert S. McDaniel, A. C. Oehlschlager
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Discovery to Engineering of Mycotoxin Deoxynivalenol Degrading Enzymes Based on the Specialized Glyoxalase I

Advanced Science, EarlyView.
Deoxynivalenol (DON), a prevalent food mycotoxin, is an important risk factor in global food safety. A molecular phylogeny‐guided engineering approach is devised to repurpose specialized glyoxalase I (SPG) as a DON deactivator. Engineered SPG variants demonstrate superior stability and are highly capable of converting DON into less toxic products ...
Seung Hee Lee, Song Lim Ham, Kyoungmi Oh, Hyojin Park, Young‐Seo Kang, Tae‐Joo Yang, Taekyung Kim, Jonghwan Kim, Gyu Sung Lee, Min‐Jeong Lee, Jin‐Byung Park, Chung Sub Kim, Nam Yoon Kim   +12 more
wiley   +1 more source

SPECIFIC FEATURES OF OLIGOMERIC PRODUCT SOLIDIFICATION FROM POLYURETHANE WASTES AND THEIR PRACTICAL APPLICATION

Наука и техника, 2012
The paper considers a possibility to use secondary polyurethane obtained by  thermal depolymerization of wastes on the basis of cross-linked polyurethane (polyurethane adduct) and isocyanate.
V. N. Belyatsky, Yu. M. Kryvogus
doaj