Results 171 to 180 of about 198,348 (348)

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source

Covalent Adducts Formed by the Androgen Receptor Transactivation Domain and Small Molecule Drugs Remain Disordered. [PDF]

J Chem Inf Model
Zhu J, Robustelli P.
europepmc   +1 more source

Mechanisms of bromination of uracil derivatives. 4. Formation of adducts in acidic aqueous solutions and their dehydration to 5-bromouracils [PDF]

, 1979
Oswald S. Tee, Sujit Banerjee
openalex   +1 more source

Ligand‐Engineered Metal–Organic Frameworks of 3D Infinite Trinuclear Zinc Units for Photocatalytic Monooxygenation of Sulfenamides

Advanced Science, EarlyView.
The rarely investigated metal–organic frameworks (MOFs) of 3D infinite trinuclear zinc units are designed and synthesized. Through controllable programming of ligands, their Lewis acidity and photoactivity are fine‐tuned to enable these MOFs as promising catalysts for the cycloaddition of CO2 and photocatalytic monooxygenation of sulfenamides and ...
Xinglei He, Chunlong Yu, Fengtao Zhang, Chenxu Gong, Jingheng Li, Ding‐Bo Zeng, Bin Zhao, Xiong Chen, Ke‐Yin Ye   +8 more
wiley   +1 more source

Thymines opposite to bulky aristolactam-DNA adducts in duplex DNA are not targeted by human thymine-DNA glycosylase. [PDF]

PeerJ
Manapkyzy D, Zhamanbayeva G, Sidorenko V, Bonala R, Johnson F, Matkarimov BT, Zharkov D, Saparbaev MK, Taipakova S.   +8 more
europepmc   +1 more source

Kinetics of DNA Adduct Formation in the Oral Cavity after Drinking Alcohol

Cancer Epidemiology, Biomarkers and Prevention, 2012
S. Balbo, Lei Meng, R. Bliss, Joni A. Jensen, D. Hatsukami, S. Hecht   +5 more
semanticscholar   +1 more source

Sustainable Electrochemical Strategy for Selective Double Bond Oxidation in the Presence of Aldehyde Groups with Mo─N─O Catalysts

Advanced Science, EarlyView.
In this work, an electrochemical strategy employing hydroperoxyl radicals and a molybdenum‐based catalyst (Mo─N─O) enables selective double‐bond oxidation in cinnamaldehyde, preserving aldehyde integrity. Under mild, energy‐efficient conditions (−200 mA), this approach converts cinnamaldehyde to benzaldehyde with complete conversion (100%) and >99 ...
Zhirong Li, Xun Zhang, Jiao Liu, Zhaomin Hao, Tengfei Zhang, Yang Yang, Yitong Wang, Santhosh Kamaraj, Jianrong Zeng, Qingsong Dong, Cuiping Zhai, Wuping Liao, Shuyan Song   +12 more
wiley   +1 more source

HR-MS Analysis of the Covalent Binding of Edaravone to 5-Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5-Formylcytidine Residue. [PDF]

Rapid Commun Mass Spectrom
Regnault R, Kouach M, Goossens L, Thuru X, Bailly C, Goossens JF.   +5 more
europepmc   +1 more source

Teratogenicity of patulin and patulin adducts formed with cysteine [PDF]

, 1976
A. Ciegler, Alfred C. Beckwith, L K Jackson   +2 more
openalex   +1 more source

EGFR‐TKIs Induced DPP4 Drives Metabolic Reprogramming of Persister Cells in Lung Cancer

Advanced Science, EarlyView.
Drug‐tolerant persister (DTP) cells emerge early during EGFR‐TKI treatment, preceding the development of acquired resistance. Elevated DPP4 in DTP cells drives metabolic reprogramming and antioxidant adaptation, promoting cell survival under drug pressure.
Yuanzhou Zhang, Xiaojun Zhang, Xupeng Yang, Xingshi Chen, Yuehong Wang, Jingying Hu, Rui Liu, Xiaoying Luo   +7 more
wiley   +1 more source