Results 261 to 270 of about 301,764 (392)
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai +7 more
wiley +1 more source
Discovery of RNA-Reactive Small Molecules Guides the Design of Electrophilic Modules for RNA-Specific Covalent Binders. [PDF]
Springer NA +4 more
europepmc +1 more source
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang +8 more
wiley +1 more source
Visualization of covalent intermediates and conformational states of proline utilization A by X-ray crystallography and molecular dynamics simulations. [PDF]
Buckley DP, Becker DF, Tanner JJ.
europepmc +1 more source
A mechanochemical method is developed using D2O and a piezoelectric catalyst to deuterate both activated and unactivated alkyl halides (Cl, Br, I) efficiently. Unlike typical mechanochemical reactions, this one starts with single‐electron oxidation. This green technique successfully deuterates various alkyl halides, including primary, secondary, and ...
Ruiling Qu +4 more
wiley +1 more source
Dirhodium Tetraacetate Binding to Lysozyme at Body Temperature. [PDF]
Tito G, Ferraro G, Merlino A.
europepmc +1 more source
3‐Hydroxylactams are obtained from phthalimides through a heterogeneous catalyzed chemoselective hydrogenation, able to stop the process at the first hydrogenation level. By using a rationally designed [Ag/Al2O3] recyclable solid nanocatalyst, a wide range of cyclic hemiamidals are accesed through a full atom‐economical reaction that preserves (hetero ...
Carles Lluna‐Galán +2 more
wiley +1 more source

