Results 261 to 270 of about 301,764 (392)

Comprehensive Measurement of Inter‐Individual Variation in DNA Repair Capacity in Healthy Individuals

open access: yesAdvanced Science, EarlyView.
Susceptibility to the health effects of DNA damage depends on a person's ability to repair DNA damage, but DNA repair has been difficult to measure in populations. A functional assay called FM‐HCR is used to measure DNA repair in 6 major pathways across 56 individuals.
Ting Zhai   +7 more
wiley   +1 more source

Arid1a Deficiency Drives Aristolochic Acid‐Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair

open access: yesAdvanced Science, EarlyView.
ARID1A is frequently mutated in both non‐malignant tissues and cancers, but its role in tumor development after exposure to genotoxic carcinogen remains unclear. It is found that aristolochic acid I accelerated liver tumorigenesis in ARID1A‐deficient context by impairing nucleotide excision repair and enhancing carcinogen bioactivation, revealing key ...
Lan Wang   +8 more
wiley   +1 more source

Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.

open access: yesCarcinogenesis, 1997
D. Ryberg   +9 more
semanticscholar   +1 more source

Mechanochemical Dehalogenative Deuteration of Alkyl Halides Through Piezoelectric Catalysis Initiated by a Single‐Electron Oxidation Strategy

open access: yesAdvanced Science, EarlyView.
A mechanochemical method is developed using D2O and a piezoelectric catalyst to deuterate both activated and unactivated alkyl halides (Cl, Br, I) efficiently. Unlike typical mechanochemical reactions, this one starts with single‐electron oxidation. This green technique successfully deuterates various alkyl halides, including primary, secondary, and ...
Ruiling Qu   +4 more
wiley   +1 more source

Controlling Selectivity at the First Hydrogenation Level: Synthesis of 3‐Hydroxyisoindolines by Heterogeneously Silver‐Catalyzed Monohydrogenation of Phthalimides

open access: yesAdvanced Science, EarlyView.
3‐Hydroxylactams are obtained from phthalimides through a heterogeneous catalyzed chemoselective hydrogenation, able to stop the process at the first hydrogenation level. By using a rationally designed [Ag/Al2O3] recyclable solid nanocatalyst, a wide range of cyclic hemiamidals are accesed through a full atom‐economical reaction that preserves (hetero ...
Carles Lluna‐Galán   +2 more
wiley   +1 more source

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