Results 321 to 330 of about 301,764 (392)

High‐Throughput Synthesis and Screening of a Cyanimide Library Identifies Selective Inhibitors of ISG15‐Specific Protease mUSP18

Angewandte Chemie, EarlyView.
Deubiquitinases (DUBs) and Ub‐like proteases are attractive but challenging drug targets. We developed a high‐throughput synthesis method and prepared a 7536‐member cyanimide DUB‐targeted compound library in 1536‐well plates, using Echo acoustic dispensing. Screening yielded a selective, 35 nM inhibitor of mUSP18, the main ISG15 protease.
Raymond Kooij, Vito Pol, Jin Gan, Bjorn R. van Doodewaerd, Aysegul Sapmaz, Marta Campos Alonso, Günter Fritz, Klaus‐Peter Knobeloch, Paul P. Geurink   +8 more
wiley   +1 more source

Effects of Different Adduct Ions, Ionization Temperatures, and Solvents on the Ion Mobility of Glycans. [PDF]

Molecules
Feng H, Yamaguchi T.
europepmc   +1 more source

Regiochemical Control of Shape Morphing in Diels-Alder Covalent Adaptable Networks. [PDF]

ACS Macro Lett
Zhao Y, Moon J, Sukhishvili SA.
europepmc   +1 more source

DNA adducts form in mouse lung and liver after oral naphthalene exposure. [PDF]

Toxicol Sci
Domanico MC, Collette NM, Ubick E, Ding X, Buchholz BA, Van Winkle LS.   +5 more
europepmc   +1 more source

An Aluminum-Based Lewis Superacid and Its Weakly Coordinating Anions Derived from an Organotellurium Ligand. [PDF]

JACS Au
Wegener D, Limberg N, Bubenik M, Pérez-Bitrián A, Wiesner A, Riedel S.   +5 more
europepmc   +1 more source

Dissecting the Diverse Reactivity of β-Diketiminate Aluminum(I) Compound towards Azaarenes: Insight From DFT Calculations. [PDF]

Chemistry
Chan KL, Lau PF, Lin Z.
europepmc   +1 more source

N-aldehyde-modified phosphatidylethanolamines generated by lipid peroxidation are robust substrates of N-acyl phosphatidylethanolamine phospholipase D. [PDF]

J Lipid Res
Fadaei R, Bernstein AC, Jenkins AN, Pickens AG, Zarrow JE, Alli-Oluwafuyi AM, Tallman KA, Davies SS.   +7 more
europepmc   +1 more source

Bridging Evolution and Design: Mapping the Diversity of LOV Photosensors

Herzog RE, Harvey-Seutcheu IF, Janke P, Dai W, Fischer PM, Hamm P, Heckmeier PJ.   +6 more
europepmc   +1 more source

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SnI4 ⋅(S8 )2 : A Novel Adduct-Type Infrared Second-Order Nonlinear Optical Crystal.

Angewandte Chemie, 2018
A simple adduct from tin tetraiodide SnI4 and octasulfur S8 , SnI4 ⋅(S8 )2 (1), is obtained employing a facile reaction. The combination of Sn4+ ions with d10 electron configuration, acentric SnI4 tetrahedra, and lone-pair effects of S8 , makes 1 a phase-
Sheng-ping Guo, Yang Chi, Huaiguo Xue
semanticscholar   +1 more source