Results 331 to 340 of about 198,348 (348)

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

Chemical Research in Toxicology, 2009
Reactive metabolite formation has been associated with drug-induced liver, skin, and hematopoietic toxicity of many drugs that has resulted in serious clinical toxicity, leading to clinical development failure, black box warnings, or, in some cases ...
J. Gan, Q. Ruan, B. He, M. Zhu, W. C. Shyu, W. Griffith Humphreys   +5 more
semanticscholar   +1 more source

N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction.

Biochemistry, 1996
Long-term incubation of proteins with glucose leads to the formation of advanced glycation end products (AGE). Recent immunological studies have suggested the potential role of AGE in atherosclerosis, aging, and diabetic complications.
K. Ikeda, T. Higashi, H. Sano, Y. Jinnouchi, Masaki Yoshida, T. Araki, S. Ueda, S. Horiuchi   +7 more
semanticscholar   +1 more source

Identification and characterization of deoxyguanosine-crotonaldehyde adducts. Formation of 7,8 cyclic adducts and 1,N2,7,8-bis-cyclic adducts

Chemical Research in Toxicology, 1992
Crotonaldehyde, a chemically reactive alpha,beta-unsaturated carbonyl compound, is an important industrial chemical and a ubiquitous environmental pollutant. It has been shown to be carcinogenic and mutagenic. We have studied the reaction of crotonaldehyde with nucleosides and 5'-mononucleotides and found three different types of adducts with ...
Erwin Eder, Christian Hoffman
openaire   +3 more sources

Amide-Adducts in Atherosclerosis

2013
Too many hypotheses in the etiology of atherosclerosis have been proposed. Classically, lipid insudation hypothesis by Virchow and thrombogenic hypothesis by Rokitansky are famous. However, in the recent progress in the area of atherosclerosis, the response-to-injury hypothesis by Ross (Ross R Glomset JA, N Engl J Med 295:369-377, 420-425, 1976; Ross R,
openaire   +3 more sources

[7] Copper-DNA adducts

1994
Publisher Summary Redox active metal ions, such as iron and copper play a central role in the formation of reactive oxygen species in biological systems. Although iron has received the most attention in this capacity, the role of copper may be particularly crucial because copper occurs naturally in chromosomes, where it is believed to play a role in ...
openaire   +3 more sources

Adducts of the Chloroform Metabolite Phosgene

2001
Chlorination of water for human consumption is important for disease prevention. However, halogenated by-products, such as trihalomethanes (THM), can be formed during this process (Bunn et al 1975). THM production raises public health concerns related to potential human cancer risk (Fawell, 2000).
Robert Edwards, Laura Fabrizi, Alan R. Boobis, Graham W. Taylor   +3 more
openaire   +3 more sources

Adduct Formation of OH With Benzene and Toluene and Reaction of the Adducts with NO and NO2

1990
The behaviour of the adducts of OH with the aromatics benzene and toluene has been studied at 130 mbar in Ar in the presence of NO and NO2 at four temperatures in the range from 300 to 350K. Biexponential decays of OH are observed in the absence of NOx and in the presence of NO. After eliminating NO2 impurities from the NO sample, the reactivity of the
Franz Witte, P. Devolder, Manfred Siese, Cornelius Zetzsch, Rainald Koch   +4 more
openaire   +2 more sources

ADDUCT CHEMISTRY AND MECHANISMS OF ADDUCT FORMATION.

Alcoholism: Clinical & Experimental Research, 2004
Simon Worrall, Lynell Warren Klassen, Dean J. Tuma, Michael F. Sorrell, Geoffrey M. Thiele, Thomas L. Freeman   +5 more
openaire   +2 more sources

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct

Science, 2001
K. Conway, J. Rochet, R. Bieganski, P. Lansbury   +3 more
semanticscholar   +1 more source

Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin

Nature, 1995
P. Takahara, A. Rosenzweig, C. Frederick, S. Lippard   +3 more
semanticscholar   +1 more source