Results 31 to 40 of about 198,348 (348)
Critical depurinating DNA adducts: Estrogen adducts in the etiology and prevention of cancer and dopamine adducts in the etiology and prevention of Parkinson's disease [PDF]
International Journal of Cancer, 2017 Endogenous estrogens become carcinogens when dangerous metabolites, the catechol estrogen quinones, are formed. In particular, the catechol estrogen-3,4-quinones can react with DNA to produce an excess of specific depurinating estrogen-DNA adducts. Loss of these adducts leaves apurinic sites in the DNA, generating subsequent cancer-initiating mutations.
Ercole L. Cavalieri +2 more
openaire +3 more sources
Clinical Chemistry, 1987 This assay of plasma lipoperoxides involves hydrolysis in dilute H3PO4 at 100 degrees C; complexation of malondialdehyde (MDA), a hydrolysis product, with thiobarbituric acid (TBA); methanol precipitation of plasma proteins; fractionation of the protein ...
Steven H Y Weng +5 more
semanticscholar +1 more source
Frontiers in ChemistryThis study presents a comprehensive structural analysis of the adducts formed upon the reaction of two Ru(III) complexes [HIsq][trans-RuIIICl4(dmso)(Isq)] (1) and [H2Ind][trans-RuIIICl4(dmso)(HInd)] (2) (where HInd–indazole, Isq–isoquinoline, analogs of ...
Maria Oszajca +6 more
doaj +1 more source
A paracetamol–morpholine adduct
Acta Crystallographica Section E Structure Reports Online, 2002 Paracetamol [also known as acetaminophen or N-(4-hydroxyphenyl)acetamide] is an important analgesic drug that has recently been cocrystallized with a series of cyclic N- and O-donor compounds. This paper describes the formation of a paracetamol adduct with morpholine, viz. paracetamol–morpholine (1/2.5), C8H9NO2·2.5C4H9NO.
Oswald, I D H +3 more
openaire +3 more sources
Why is Aged Acetylcholinesterase So Difficult to Reactivate?
Molecules, 2017 Organophosphorus agents are potent inhibitors of acetylcholinesterase. Inhibition involves successive chemical events. The first is phosphylation of the active site serine to produce a neutral adduct, which is a close structural analog of the acylation ...
Daniel M. Quinn +3 more
doaj +1 more source
Scientific Reports, 2021 Cyclophosphamide (CPA) dosing by body surface area (BSA, m2) has been questioned as a predictor for individual drug exposure. This study investigated phosphoramide mustard-hemoglobin (PAM-Hb, pmol g−1 Hb) as a biomarker of CPA exposure in 135 female ...
S. A. M. Gernaat +6 more
doaj +1 more source
Journal of the American Chemical Society, 2010 A poly(3-hexylthiophene) (P3HT)-based inverted solar cell using indene-C60 bis-adduct (ICBA) as the acceptor achieved a high open-circuit voltage of 0.82 V due to ICBA's higher-lying lowest unoccupied molecular orbital level, leading to an exceptional ...
Yen‐Ju Cheng +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Reactive Carbonyl Species Scavenger: Epigallocatechin-3-Gallate
FoodsEpigallocatechin-3-gallate (EGCG), a prominent polyphenol found abundantly in tea, has garnered significant attention for its potential in preventing and ameliorating a wide range of diseases.
Haiying Luo, Juanying Ou, Junqing Huang
doaj +1 more source
Structures of the reaction products of the AZADO radical with TCNQF4 or thiourea
Beilstein Journal of Organic Chemistry, 2013 While an addition product was formed by the reaction of AZADO (2-azaadamantane N-oxyl) with TCNQF4 (2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane), the reaction of AZADO with thiourea provided an inclusion compound, in which AZADO molecules are ...
Hideto Suzuki +4 more
doaj +1 more source