Results 51 to 60 of about 207,770 (335)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Differentiating signals to make biological sense – a guide through databases for MS-based non-targeted metabolomics [PDF]

, 2017
Metabolite identification is one of the most challenging steps in metabolomics studies and reflects one of the greatest bottlenecks in the entire workflow.
Armitage, Emily Grace, Barbas, Coral, Gil de la Fuente, Alberto, Godzien, Joanna, Otero, Abraham   +4 more
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Associations between Serum Aflatoxin-B1 and Anemia in Pregnant Women: Evidence from Guangxi Zhuang Birth Cohort in China

Toxins, 2021
Aflatoxin B1 (AFB1) is a common toxic mycotoxin and is detectable in pregnant women. Animal studies have revealed that AFB1 caused the lysis of erythrocytes and a decrease in hemoglobin. We conducted a prospective cohort study in Guangxi, China, in order
Lei Lei, Shun Liu, Ye Ye, Xiaoqiang Qiu, Dongping Huang, Dongxiang Pan, Jiehua Chen, Zhengmin Qian, Stephen Edward McMillin, Michael G. Vaughn, Xingxi Luo, Kaili Wu, Suyang Xiao, Jinxiu Li, Meiliang Liu, Yu Yang, Mingshuang Lai, Guanghui Dong, Xiaoyun Zeng   +18 more
doaj   +1 more source

Spontaneous dehydrocoupling in peri-substituted phosphine-borane adducts [PDF]

, 2016
This work was financially supported by the EPSRC and COST action CM1302 SIPs.Bis(borane) adducts Acenap(PiPr2·BH3)(PRH·BH3) (Acenap = acenaphthene-5,6-diyl; 4a, R = Ph; 4b, R = ferrocenyl, Fc; 4c, R = H) were synthesised by the reaction of excess H3B ...
Cordes, David Bradford, Kilian, Petr, Ray, Matthew James, Slawin, Alexandra Martha Zoya, Surgenor, Brian Andrew, Taylor, Laurence John, Wawrzyniak, Piotr   +6 more
core   +2 more sources

Chronological and Spatial Distribution of Skeletal Muscle Fat Replacement in FHL1‐Related Myopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Variants in the FHL1 gene cause FHL1‐related myopathies (FHL1‐RMs), a group of neuromuscular disorders with diverse clinical presentations. This study aimed to comprehensively characterize the spatial and temporal patterns of skeletal muscle fat replacement throughout the whole body in FHL1‐RMs, to examine disease progression over ...
Rui Shimazaki, Satoru Noguchi, Hotake Takizawa, Yasushi Oya, Yuji Takahashi, Hirofumi Komaki, Hajime Arahata, Shinichiro Hayashi, Ichizo Nishino   +8 more
wiley   +1 more source

Exploring the coordination chemistry of ruthenium complexes with lysozymes: structural and in-solution studies

Frontiers in Chemistry
This study presents a comprehensive structural analysis of the adducts formed upon the reaction of two Ru(III) complexes [HIsq][trans-RuIIICl4(dmso)(Isq)] (1) and [H2Ind][trans-RuIIICl4(dmso)(HInd)] (2) (where HInd–indazole, Isq–isoquinoline, analogs of ...
Maria Oszajca, Monika Flejszar, Monika Flejszar, Arkadiusz Szura, Patrycja Dróżdż, Małgorzata Brindell, Katarzyna Kurpiewska   +6 more
doaj   +1 more source

Step-Wise Computational Synthesis of Fullerene C60 derivatives. 1.Fluorinated Fullerenes C60F2k

, 2009
The reactions of fullerene C60 with atomic fluorine have been studied by unrestricted broken spin-symmetry Hartree-Fock (UBS HF) approach implemented in semiempirical codes based on AM1 technique. The calculations were focused on a sequential addition of
A. A. Gakh, A. A. Gakh, A. A. Gakh, A. A. Gakh, A. A. Popov, A. Szabo, B. W. Clare, B. W. Clare, B. W. Clare, B. W. Clare, B. W. Clare, D. A. Zhogolev, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. F. Sheka, E. R. Davidson, F. N. Tomilin, H. Zabrodsky, I. Kaplan, I. S. Neretin, J. A. Pople, J. H. Holloway, J. Hachmann, K. B. Wiberg, K. Balasubramania, K. Hedberg, K. Takatsuka, L. G. Bulusheva, L. Hedberg, L. Noodleman, N. Matsuzawa, O. V. Boltalina, O. V. Boltalina, P. J. Krusic, P. K. Berzigiyarov, R. J. Papoular, R. L. Jaffe, R. Mitsumoto, R. Taylor, R. Taylor, S. Dutta, S. G. Semenov, S. Grimme, S. I. Troyanov, S. Kawasaki, U. Barth von, V. N. Staroverov   +54 more
core   +1 more source

Changes in the milk metabolome of the Giant Panda (Ailuropoda melanoleuca) with time after birth: three phases in early lactation and progressive individual differences [PDF]

, 2015
Ursids (bears) in general, and giant pandas in particular, are highly altricial at birth. The components of bear milks and their changes with time may be uniquely adapted to nourish relatively immature neonates, protect them from pathogens, and support ...
Hou, Rong, Kennedy, Malcolm W., Loeffler, I. Kati, Wang, Hairui, Watson, David G., Zhang, Liang, Zhang, Rong, Zhang, Tong, Zhang, Zhihe   +8 more
core   +3 more sources

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source