Evaluation of Adefovir PBPK Model to Assess Biomarker‐Informed OAT1 Drug–Drug Interaction and Effect of Chronic Kidney Disease [PDF]
CPT: Pharmacometrics & Systems PharmacologyEvaluation of transporter‐mediated drug–drug interactions (DDI) with endogenous biomarkers, coupled with physiologically‐based pharmacokinetic modeling (PBPK) is envisioned to replace or reduce dedicated DDI clinical trials with clinical probe substrates.
Shawn Pei Feng Tan +4 more
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Adefovir dipivoxil inhibits APL progression through degradation of the oncoprotein PML-RARA [PDF]
Experimental Hematology & Oncology, 2022 Acute promyelocytic leukemia (APL) is highly aggressive and is frequently associated with disseminated intravascular coagulation and high early death rates. Although all-trans retinoic acid (RA) induces complete remission in a high proportion of patients
Xubo Gong +9 more
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Adefovir dipivoxil-induced hypophosphatemic osteomalacia and osteoporosis: a case report and literature review [PDF]
Frontiers in EndocrinologyThe nephrotoxicity of adefovir dipivoxil (ADV) can induce Fanconi syndrome, which causes hypophosphatemic osteomalacia. We report a case of a 67-year-old postmenopausal woman who had been receiving long-term adefovir dipivoxil therapy for chronic ...
Wenshu Yu +4 more
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Follow-Up of Adefovir Dipivoxil Induced Osteomalacia: Clinical Characteristics and Genetic Predictors [PDF]
Frontiers in Pharmacology, 2021 Adefovir dipivoxil (ADV) is widely used for chronic hepatitis B therapy in China. To explore the clinical features and prognosis of ADV-induced osteomalacia and to analyze the association between osteomalacia and genetic variants in 51 drug transporters ...
Jiao Zhao +5 more
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Adefovir dipivoxil-associated Fanconi syndrome combined with peripheral neuropathy: a case report and literature review [PDF]
Frontiers in PharmacologyLong-term use of low-dose adefovir dipivoxil (ADV) has been increasingly associated with Fanconi syndrome; however, cases of Fanconi syndrome combined with peripheral neuropathy remain rare.
Shanshan Fu +3 more
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Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report [PDF]
BMC Pharmacology and Toxicology, 2020 Background Progressive bone pain and fracture and abnormal positron emission tomography combined with a computed tomography are main reasons for the oncologists suspecting bone tumor. During the patient’s medical treatment, the oncologists’ unfamiliarity
Qian Xiang +8 more
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Fanconi syndrome induced by adefovir dipivoxil: a case report and clinical review [PDF]
Journal of International Medical Research, 2020 More than 150 cases of Fanconi syndrome (FS) or hypophosphatemia osteomalacia induced by low-dose adefovir dipivoxil (ADV) have been reported since 2002, when ADV was introduced for the long-term treatment of hepatitis B virus (HBV) infection.
Kaixin Song +9 more
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Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series [PDF]
BMC Pharmacology and Toxicology, 2018 Background Adefovir dipivoxil (ADV)-induced renal tubular dysfunction and hypophosphatemic osteomalacia (HO) have been given great consideration in the past few years.
Nan Chen +9 more
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Acta Médica Costarricense, 2008 El adefovir es un nucleótido que se utiliza por vía oral, sin resistencia conocida hasta los dos años de tratamiento. Actúa en los pacientes con hepatitis B crónica Age+ y Age-, es efectivo en resistentes a lamivudina.
Francisco Javier Hevia-Urrutia
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Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance [PDF]
Drug Design, Development and Therapy, 2015 Guiliang Wang,1,2 Yan Liu,2 Ping Qiu,1 Shu-Feng Zhou,3,4 Linfang Xu,1 Ping Wen,1 Jianbo Wen,1 Xianzhong Xiao5 1Department of Digestive Internal Medicine, Gannan Medical University Pingxiang Hospital, Pingxiang, People’s Republic of China ...
Wang G +7 more
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