Results 1 to 10 of about 300,709 (196)

Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study [PDF]

Open Veterinary Journal
Background: Adenine is a naturally occurring purine essential for life, but its excess intake can cause metabolic disturbances leading to cardiovascular complications, renal stones, gout, fatigue, and anemia.
Waleed Khaled Y. Albahadly, Mohammed Jasim Jawad, Mohammed Ibrahim Rasool, Haider Falih ShamikhAl-Saedi, Asia Ali Hamza   +4 more
doaj   +2 more sources

Construction and Anti-Cancer Activity of a Self-Assembly Composite Nano-Delivery System Loaded with Curcumin [PDF]

Molecules
Natural products possess potent pharmacological activities and health benefits. However, drawbacks such as water insolubility, poor stability, and low bioavailability limit their practical applications.
Liang Chen, Qiao Wu, Chen Yang, Xiulan Xin, Zhaochu Xu, Shuai Luo, Hao Liang   +6 more
doaj   +2 more sources

Insight into G-quadruplex-hemin DNAzyme/RNAzyme: adjacent adenine as the intramolecular species for remarkable enhancement of enzymatic activity [PDF]

Nucleic Acids Research, 2016
G-quadruplex (G4) with stacked G-tetrads structure is able to bind hemin (iron (III)-protoporphyrin IX) to form a unique type of DNAzyme/RNAzyme with peroxidase-mimicking activity, which has been widely employed in multidisciplinary fields.
Wang Li, Yong Li, Zhuoliang Liu, Bin Lin, Haibo Yi, Feng Xu, Zhou Nie, Shouzhuo Yao   +7 more
openalex   +2 more sources

Repurposing an adenine riboswitch into a fluorogenic imaging and sensing tag

Nature Chemical Biology, 2021
Sourav Dey, Grigory S. Filonov, Anthony O. Olarerin-George, Benjamin T. Jackson, Lydia W.S. Finley, Samie R. Jaffrey   +5 more
openalex   +3 more sources

Preventive effects of the Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple on chronic kidney disease rats via modulating the intestinal microbiota and enhancing the intestinal barrier

Frontiers in Pharmacology, 2022
CKD is a clinical syndrome with slow development and gradual deterioration of renal function. At present, modern medicine still lacks an ideal treatment method for this disease, while TCM has accumulated rich clinical experience in the treatment of CKD ...
Ling Wang, Ling Wang, Jin-Hui Zhu, Jin-Hui Zhu, Xiao-Dan Jiang, Xiao-Dan Jiang, Zhen-Xiang Ma, Zhen-Xiang Ma, Jin-Hua Tao, Jin-Hua Tao, Jin-Hua Tao   +10 more
doaj   +1 more source

Effect of fetuin-A on adenine-induced chronic kidney disease model in male rats [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): This study aimed to investigate the possible effects of fetuin-A on an adenine-induced chronic kidney disease (CKD) model in male rats.
Wesam Ashour, Mohamed Sayed Ahmed Zamzam, Heba Essam El Din El Sayed Ali, Reham Hassan Ebrahim   +3 more
doaj   +1 more source

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Nature Biotechnology, 2021
Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the livers of mice and cynomolgus macaques for ...
Tanja Rothgangl, Melissa K Dennis, Paulo J. C. Lin, Rurika Oka, D. Witzigmann, L. Villiger, W. Qi, M. Hrůzová, Lucas Kissling, Daniela Lenggenhager, Costanza Borrelli, S. Egli, Nina Frey, Noëlle Bakker, John A. Walker, A. Kadina, D. Victorov, Martin Pacesa, Susanne Kreutzer, Zacharias Kontarakis, A. Moor, M. Jinek, D. Weissman, M. Stoffel, R. van Boxtel, K. Holden, N. Pardi, B. Thöny, J. Häberle, Ying K. Tam, S. Semple, Gerald Schwank   +31 more
semanticscholar   +1 more source

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Nature Biotechnology, 2022
Improved cytosine base editors are generated by phage-assisted evolution of a deoxyadenosine deaminase. Cytosine base editors (CBEs) are larger and can suffer from higher off-target activity or lower on-target editing efficiency than current adenine base
M. Neugebauer, Alvin Hsu, Mandana Arbab, Nicholas A Krasnow, A. McElroy, Smriti Pandey, Jordan L. Doman, Tony P. Huang, Aditya Raguram, Samagya Banskota, Gregory A. Newby, J. Tolar, Mark J. Osborn, David R. Liu   +13 more
semanticscholar   +1 more source

The Non-Equilibrium Thermodynamics of Natural Selection: From Molecules to the Biosphere

Entropy, 2023
Evolutionary theory suggests that the origin, persistence, and evolution of biology is driven by the “natural selection” of characteristics improving the differential reproductive success of the organism in the given environment.
Karo Michaelian
doaj   +1 more source

Alteration in the molecular structure of the adenine base exposed to gamma irradiation: An ESR study

Open Chemistry, 2023
Adenine polycrystals were obtained from their powder form under effective crystallization conditions by adjustment of the concentration of chemical solutions. The adenine samples were irradiated with a 60Co gamma-ray source at room temperature for 12, 24,
Usta Keziban
doaj   +1 more source