Results 91 to 100 of about 417,743 (333)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Adenine Abundance in a Collapsing Molecular Cloud [PDF]

, 2000
A vital ingredient of DNA molecule named adenine may be produced by successive addition of HCN during molecular cloud collapse and star formation. We compute its abundance in a collapsing cloud as a function of the reaction rate and show that in much of ...
Chakrabarti, Sandip K., Chakrabarti, Sonali   +1 more
core   +1 more source

Calculations of the Exciton Coupling Elements Between the DNA Bases Using the Transition Density Cube Method

, 2007
Excited states of the of the double-stranded DNA model (A)$_{12}\cdot$(T)_{12} were calculated in the framework of the exciton theory. The off-diagonal elements of the exciton matrix were calculated using the transition densities and ideal dipole ...
Bittner, Eric R., Czader, Arkadiusz
core   +1 more source

Dual-tip-enhanced ultrafast CARS nanoscopy [PDF]

, 2013
Coherent anti-Stokes Raman scattering (CARS) and, in particular, femtosecond adaptive spectroscopic techniques (FAST CARS) have been successfully used for molecular spectroscopy and microscopic imaging.
, Aeschlimann M, Agio M, Alexander M Sinyukov, Alexei V Sokolov, Biagioni P, Bin Cao, Charles W Ballmann, Dmitri V Voronine, Mukamel S, Palik E D, Potma E O, Rice S A, Ru E C L, Schluecker S, Shapiro M   +15 more
core   +3 more sources

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Radiological Evaluation of Huntington’s Disease: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
Huntington’s Disease (HD) is a rare neurodegenerative condition inherited in an autosomal dominant pattern, where Gamma Amino Butyric Acid-ergic (GABAergic) neurons in the basal ganglia progressively deteriorate.
Soumyabrata Debnath, R Harshith
doaj   +1 more source

Selective Benzene Capture by Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
Metal‐organic frameworks (MOFs) hold significant potential for capturing benzene from air emissions and hydrocarbon mixtures in liquid phases. This capability stems from their precisely engineered structures, versatile chemistries, and diverse binding interactions.
Zongsu Han, Ankit Mondal, Jiatong Huo, Yihao Yang, Hong‐Cai Zhou   +4 more
wiley   +1 more source

Fox grape cv. Bordô (Vitis labrusca L.) and grapevine cv. Chardonnay (Vitis vinifera L.) cultivated in vitro under different carbohydrates, amino acids and 6-Benzylaminopurine levels

Brazilian Archives of Biology and Technology, 2013
The aim of this work was to study the influence of sucrose and glucose, amino acids and BAP (6-Benzylaminopurine) levels on in vitro shoot regeneration of fox grape cv. Bordô and grapevine cv. Chardonnay.
Dayse Cristina de Carvalho, André Luís Lopes da Silva, Mariane Ruzza Schuck, Marivel Purcino, Guilherme Nakao Tanno, Luiz Antonio Biasi   +5 more
doaj  

Adenine-induced animal model of chronic kidney disease: current applications and future perspectives

Renal Failure
Chronic kidney disease (CKD) with high morbidity and mortality all over the world is characterized by decreased kidney function, a condition which can result from numerous risk factors, including diabetes, hypertension and obesity.
Qiao Yang, Songya Su, Nan Luo, Gang Cao
doaj   +1 more source

Position Effect Takes Precedence Over Target Sequence in Determination of Adenine Methylation Patterns in the Nuclear Genome of a Eukaryote, \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1998
Approximately 0.8% of the adenine residues in the macronuclear DNA of the ciliated protozoan Tetrahymena thermophila are modified to N6-methyladenine. DNA methylation is site specific and the pattern of methylation is constant between clonal cell lines ...
Karrer, Kathleen M., Van Nuland, Teresa A.   +1 more
core   +1 more source