Uraemic Cardiomyopathy in Different Mouse Models
Frontiers in Medicine, 2021 Uraemic cardiomyopathy (UCM) is one of the most common complications in chronic kidney disease (CKD). Our aim was to compare characteristics of various UCM mouse models. Mice were assigned to the following groups: the pole ligation group, 5/6 nephrectomy
Cheng Chen +7 more
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Adenine Nucleotide and Nicotinamide Adenine Dinucleotide Measurements in Plants [PDF]
Current Protocols in Plant Biology, 2020 AbstractAs the principal co‐factors of many metabolic pathways, the measurement of both adenine nucleotides and nicotinamide adenine dinucleotide provides important information about cellular energy metabolism. However, given their rapid and reversible conversion as well as their relatively low concentration ranges, it is difficult to measure these ...
Zhang, Youjun +4 more
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Adenine Phosphoribosyltransferase Deficiency [PDF]
Clinical Journal of the American Society of Nephrology, 2012 Summary Complete adenine phosphoribosyltransferase (APRT) deficiency is a rare inherited metabolic disorder that leads to the formation and hyperexcretion of 2,8-dihydroxyadenine (DHA) into urine. The low solubility of DHA results in precipitation of this compound and the formation of urinary crystals and stones.
Guillaume, Bollée +5 more
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Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]
, 2015 MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng +6 more
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Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2014 African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential.
Lüscher, Alexandra +4 more
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Electron transfer driven decomposition of adenine and selected analogs as probed by experimental and theoretical methods [PDF]
, 2018 We report on a combined experimental and theoretical study of electron transfer induced decomposition of adenine and a selection of analogue molecules in collisions with potassium atoms (K).
Bacchus-Montabonel, M.-C. +6 more
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Adsorption of Nucleic Acid Bases, Ribose, and Phosphate by Some Clay Minerals
Life, 2015 Besides having a large capacity for taking up organic molecules, clay minerals can catalyze a variety of organic reactions. Derived from rock weathering, clay minerals would have been abundant in the early Earth. As such, they might be expected to play a
Hideo Hashizume
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DGR mutagenic transposition occurs via hypermutagenic reverse transcription primed by nicked template RNA. [PDF]
, 2017 Diversity-generating retroelements (DGRs) are molecular evolution machines that facilitate microbial adaptation to environmental changes. Hypervariation occurs via a mutagenic retrotransposition process from a template repeat (TR) to a variable repeat ...
Guo, Huatao +6 more
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Adenine and Thymine Effect on Quartz Dissolution at Different Artificial Seawaters
Orbital: The Electronic Journal of Chemistry, 2018 According to Bernal (1951) minerals may have played important roles in the origin of life such as: protect biomolecules against degradation by UV radiation or hydrolysis, pre-concentrate biomolecules from prebiotic seas and formation of polymers.
Dimas Augusto Morozin Zaia +2 more
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Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]
, 2016 Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P. +4 more
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