Infrared Spectral Signatures of Nucleobases in Interstellar Ices I: Purines
The purine nucleobases adenine and guanine are complex organic molecules that are essential for life. Despite their ubiquitous presence on Earth, purines have yet to be detected in observations of astronomical environments.
Caroline Antunes Rosa+11 more
doaj +1 more source
Synthesis of purines and adenines containing the hexafluoroisopropyl group
Several new derivatives of adenine, purine, and theophylline containing the (CF3)2CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (1) with the corresponding ...
Viacheslav Petrov+5 more
doaj +1 more source
Sensitive Silver-Enhanced Microplate Apta-Enzyme Assay of Sb3+ Ions in Drinking and Natural Waters
The toxic effects of antimony pose risks to human health. Therefore, simple analytical techniques for its widescale monitoring in water sources are in demand. In this study, a sensitive microplate apta-enzyme assay for Sb3+ detection was developed.
Nadezhda S. Komova+4 more
doaj +1 more source
(1RS,2RS,6RS)-2-(6-Amino-9H-purin-9-yl)-8-azaspiro[5.6]dodec-10-en-1-ol Dihydrochloride
The title compound (1RS,2RS,6RS)-2-(6-Amino-9H-purin-9-yl)-8-azaspiro[5.6]dodec-10-en-1-ol dihydrochloride was synthesized for the first time in two steps, the first of which was a regioselectivity of epoxide ring-opening reaction under the action of ...
Ildar R. Iusupov+3 more
doaj +1 more source
A porous material (PEA) was prepared by the ring opening polymerization of polyethylene glycol diglycidyl ether with adenine in a simple sol-gel method. The structure and composition of PEA were characterized by SEM, FT-IR, BET and XRD.
Longfei Zhang+7 more
doaj +1 more source
Electron transfer driven decomposition of adenine and selected analogs as probed by experimental and theoretical methods [PDF]
We report on a combined experimental and theoretical study of electron transfer induced decomposition of adenine and a selection of analogue molecules in collisions with potassium atoms (K).
Bacchus-Montabonel, M.-C.+6 more
core +3 more sources
Adsorption of Nucleic Acid Bases, Ribose, and Phosphate by Some Clay Minerals
Besides having a large capacity for taking up organic molecules, clay minerals can catalyze a variety of organic reactions. Derived from rock weathering, clay minerals would have been abundant in the early Earth. As such, they might be expected to play a
Hideo Hashizume
doaj +1 more source
This work aimed to investigate whether treatment with the antidiabetic drug metformin would affect adenine-induced chronic kidney disease (CKD) in non-diabetic rats and rats with streptozotocin (STZ)-induced diabetes.
Mohammed Al Za’abi+7 more
doaj +1 more source
Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]
MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng+6 more
core +2 more sources
The Dissipative Photochemical Origin of Life: UVC Abiogenesis of Adenine
The non-equilibrium thermodynamics and the photochemical reaction mechanisms are described which may have been involved in the dissipative structuring, proliferation and complexation of the fundamental molecules of life from simpler and more common ...
Karo Michaelian
doaj +1 more source